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  • Electronic Resource  (7)
  • 2000-2004  (5)
  • 1965-1969  (2)
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  • Electronic Resource  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Cysteinyl leukotriene-dependent interleukin-5 production leading to eosinophilia during late asthmatic response in guinea-pigs (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Allergic airway eosinophilia is suppressed by cysteinyl leukotriene (CysLT) receptor (CysLT1 receptor) antagonists in several species including humans and guinea-pigs, suggesting that CysLTs are directly or indirectly involved in induction of the response.Objective We examined the effect of CysLT antagonists (pranlukast and MCI-826) on antigen inhalation-induced eosinophilia in peripheral blood and lung, and on IL-5 activity in serum during late increase of airway resistance (late asthmatic response, LAR) in sensitized guinea-pigs.Methods Guinea-pigs inhaled ovalbumin (OVA) + Al(OH)3 and OVA mists alternately for sensitization and challenge, respectively, once every 2 weeks. At the fifth challenge, the effects of CysLT antagonists and an anti-IL-5 antibody (TRFK-5) on the occurrence of LAR, and blood and lung eosinophilia, which appeared at 5 h after challenge, were examined. The time-course of IL-5 activity in the serum after the challenge was evaluated by measuring in vitro‘eosinophil survival prolongation activity’. The influence of CysLT antagonists on IL-5 activity was assessed.Results CysLT antagonists and TRFK-5 completely abolished blood and lung eosinophilia. LAR was suppressed by both MCI-826 and TRFK-5 by 40–50%. Sera obtained from sensitized, challenged animals 3 h and 4 h after challenge induced an obvious prolongation of eosinophil survival. The activity of the sera was completely neutralized by prior exposure to TRFK-5, suggesting that it reflected IL-5 activity. Increased IL-5 activity in the serum was inhibited by both pranlukast and MCI-826 by over 90%.Conclusions CysLTs produced after antigen provocation sequentially induced IL-5 production from some immune component cells via CysLT1 receptor activation. Thus, it is likely that CysLTs indirectly cause antigen-induced eosinophilia through IL-5 production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0954-7894.2002.01329.x
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  • 2
    Electronic Resource
    Electronic Resource
    Blockade of superoxide generation prevents high-affinity immunoglobulin E receptor-mediated release of allergic mediators by rat mast cell line and human basophils (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Previous studies have shown that rat peritoneal mast cells and mast cell model rat basophilic leukaemia (RBL-2H3) cells generate intracellular reactive oxygen species (ROS) in response to antigen challenge. However, the physiological significance of the burst of ROS is poorly understood.Objective The present study was undertaken to investigate the role of superoxide anion in mediator release in rat and human cell systems.Methods RBL-2H3 cells were directly stimulated with anti-rat FcεRI α-subunit monoclonal antibody (mAb). For the analysis of human cell system, leucocytes were isolated by dextran sedimentation from healthy volunteers or from patients, and challenged either with anti-human FcεRI mAb or with the relevant antigens. Superoxide generation was determined by chemiluminescence-based methods. The releases of histamine and leukotrienes (LT)s were determined by enzyme-linked immunosorben assay (ELISA).Results Cross-linking of FcεRI on RBL-2H3 cells or on human leucocytes from healthy donors by the anti-FcεRI mAb resulted in a rapid generation of superoxide anion, as determined by chemiluminescence using superoxide-specific probes. Similarly, leucocytes from patients generated superoxide anion in response to the challenge with the relevant allergen but not with the irrelevant allergen. Furthermore, diphenyleneiodonium (DPI), a well-known inhibitor of flavoenzymes suppressed the superoxide generation and the release of histamine and LTC4 induced by the anti-FcεRI mAb or by allergen in parallel.Conclusion These results indicate that both RBL-2H3 cells and human basophils generate superoxide anion upon FcεRI cross-linking either by antibody or by allergen challenge and that blockade of the generation prevents the release of allergic mediators. The findings strongly support the role of superoxide generation in the activation of mast cells and basophils under both physiological and pathological conditions. The findings suggest that drugs regulating the superoxide generation have potential therapeutic use for allergic disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0954-7894.2002.01263.x
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  • 3
    Electronic Resource
    Electronic Resource
    Periodontal status and serum antibody titers for Porphyromonas gingivalis fimbriae in a rural population in Japan (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background, aims: The present study was undertaken to assess the periodontal status of a rural Japanese population and to study the correlation between the periodontal status and the serum antibody titers for Porphyromonas gingivalis (Pg) fimbriae.Method: A total of 236 individuals were examined for their periodontal conditions by the use of the community periodontal index for treatment needs (CPITN), and serum antibody titers for Pg fimbriae in their peripheral blood samples were evaluated using the enzyme-linked immunosorbent assay.Results: There was a substantially larger proportion of edentulous subjects in the age group older than 60 years. The remaining teeth were 24.1, 23.2, 11.1 and 10.1 per person in the 40–49, 50–59, 60–69 and 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE280311:ges" location="ges.gif"/〉70 age groups, respectively. The % of sextants with a CPITN code of missing sextant (MS) increased towards elderly and reached 〉60% in the age group of 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE280311:ges" location="ges.gif"/〉70 years, as the % of the CPITN 2, 1 or 0 sextant decreased. The % of CPITN 4 and 3 sextants did not differ between different age groups and were about 6–8% and 15–20%, respectively. The % of CPITN 1 or 0 sextants was higher in female subjects than in male subjects in the 60–69 and 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:03036979:JCPE280311:ges" location="ges.gif"/〉70 age groups, while the % of CPITN 4 or 3 sextants was higher in male subjects than in female subjects in all age groups. There was no significant difference between various age groups in the mean serum antibody titers for Pg fimbriae. The mean anti-Pg fimbriae antibody titers was significantly higher for the subjects with a maximum CPITN code 4 (max.-CPITN 4 subject) than for the subjects with lower maximum CPITN codes. The antibody titers varied extensively among the max.-CPITN 4 or 3 subjects, but not among the max.-CPITN 2/1/0 or MS subjects.Conclusions: The present study demonstrated that tooth loss is a remarkable event in elderly subjects and that oral prophylaxis and mechanical debridement should be mandatory in the population examined. It was also demonstrated that the serum antibody titers against Pg fimbriae could be useful for screening individuals with moderate to severe periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2001.028003264.x
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  • 4
    Electronic Resource
    Electronic Resource
    A short timescale for terrestrial planet formation from Hf–W chronometry of meteorites (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 418 (2002), S. 949-952 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Determining the chronology for the assembly of planetary bodies in the early Solar System is essential for a complete understanding of star- and planet-formation processes. Various radionuclide chronometers (applied to meteorites) have been used to determine that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature00995
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  • 5
    Electronic Resource
    Electronic Resource
    Adrenal 17-Hydroxycorticosteroid secretion in response to cyanide anoxia (1965)
    Springer
    Pflügers Archiv 285 (1965), S. 119-123 
    Details
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Adrenal venous blood samples were collected from conscious dogs and analysed for 17-hydroxycorticosteroids (17-OHCS) and catechol amines. Potassium cyanide was administered subcutaneously in doses of 1.0–4.0 mg/kg. The pre-injection secretion rates of 17-OHCS per gland were 0.02–0.26 μg/kg/min. In all the experiments, the 17-OHCS secretion rates increased after cyanide injection to maximal values of 0.60–1.55 μg/kg/min. After injection of 1.0–3.0 mg/kg cyanide, the adrenal medullary secretion rates remained unchanged. Dogs given 4.0 mg/kg cyanide had elevated adrenal medullary secretion rates when anoxic symptoms, such as convulsions, were manifested. The present findings suggest that adrenal cortical response is more sensitive than adrenal medullary response to cyanide anoxia.
    Notes: Zusammenfassung Nebennierenvenenblut wurde an nicht narkotisierten und nicht gefesselten Hunden entnommen und der Gehalt an 17-Hydroxycorticosteroiden (17-OHCS) und Catechinaminen abgeschätzt. KCN wurde in Dosen von 1,0–4,0 mg pro Kilogramm Körpergewicht subcutan eingespritzt. Die Sekretionsgeschwindigkeit von 17-OHCS vor der Injektion betrug 0,02–0,26 μg pro Minute und Kilogramm Körpergewicht. Nach der Injektion war bei allen Dosierungen die Sekretionsgeschwindigkeit stark beschleunigt. Die höchsten Werte betrugen 0,60–1,55 μg pro Minute und Kilogramm. KCN in Dosen von 1,0–3,0 mg pro Kilogramm rief keine Hypersekretion des Nebennierenmarks, dagegen in der Dose von 4,0 mg pro Kilogramm eine ausgiebige Vergrößerung der Sekretionsgeschwindigkeit des Nebennierenmarks hervor. In den vorliegenden Experimenten finden wir demnach einen Hinweis darauf, daß der Sekretionsmechanismus von Nebennierenrinde gegen der Blausäurevergiftung empfindlicher als der von Nebennierenmark ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363222
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  • 6
    Electronic Resource
    Electronic Resource
    Diffuse component of the cosmic far UV radiation and interstellar dust grains (1969)
    Springer
    Astrophysics and space science 5 (1969), S. 493-502 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The diffuse far UV radiation (λλ 1350–1480 Å) observed in the sky region ofl II≈180°, 0°≤b II≲40° is analyzed in connection with the distributions of stars and dust grains as well as with optical properties of grains. Its intensity (starlight+scattered light) is about 6×10−7 erg cm−2 sec−1 sr−1 Å−1 in the direction ofb II≈0° andl II≈180°. The latitude dependence of the intensity is in approximate agreement with the plane parallel slab model of the galaxy with a reasonable set of parameters. The interstellar scattering gives an albedo close to unity and forward phase function of about 0.6, which are not inconsistent with the model of interstellar grains of Wickramasinghe. The upper limit of the extragalactic UV is 2×10−8 erg cm−2 sec−1 sr−1 Å−1 in the same region of wave-length.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652397
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  • 7
    Electronic Resource
    Electronic Resource
    Photoinduced electron transfer catalysis of titania particles modified with a Ru(2,2′-bipyridyl)3 2+-grafted polymer by visible light (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 481-484 
    Details
    ISSN: 1435-1536
    Keywords: Key words Hybrid titania ; Photocatalysis ; Visible light ; Ru(2 ; 2′-bipyridyl)3Cl2 ; Polymer modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The preparation and photocatalysis of colloidal titania modified with Ru(2,2′-bipyridyl)3 2+-grafted polyacrylate were investigated. Visible light irradiation of the Ru(2,2′-bipyridyl)3 2+-tethered titania in pH 7.0 buffer solution gave electron transfer to methyl viologen to form the cation radical via electron migration from the Ru(II) complex to the titania surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050543
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