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  • 2005-2009  (7)
  • 1965-1969  (10)
  • 1950-1954  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    FORMATION AND TURNOVER OF THE MAJOR BRAIN GANGLIOSIDES DURING DEVELOPMENT (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 14 (1967), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1967.tb09582.x
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  • 2
    Electronic Resource
    Electronic Resource
    AN EXPERIMENTAL PROCEDURE FOR THE MEASUREMENT OF THE GANGLIOSIDE RADIOACTIVITY LABELLED IN VIVO (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 14 (1967), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1967.tb09581.x
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  • 3
    Electronic Resource
    Electronic Resource
    Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan.Aim : To estimate the preventive effect by normal dose, not high-dose histamine-H2 receptor antagonists (H2RA) for NSAID-induced ulcers.Methods : We designed two different studies to assess the efficacy of anti-ulcer agents in rheumatoid arthritis (RA) in patients treated over a long term with NSAIDs. An investigative survey divided patients into those not taking anti-ulcer agents (non-medication group); those taking mucosal protective agents (mucosal protectant group), H2RA (H2RA group), proton pump inhibitors (PPI group), or a prostaglandin E1 analog (PG) (PG group). The second study compared prospectively the preventive effects of either famotidine 20 mg bd (famotidine group) or lansoprazole 15 mg daily (lansoprazole group) in patients with PU scars.Results : The prevalence of PU in the H2RA group was significantly lower compared to the mucosal protectant group (P 〈 0.05), and the mucosal protectant group was not significantly different to the non-medication group. The prospective study revealed that the PU onset rate of the famotidine group was 8% (1/13), and lansoprazole group was 15% (2/13), indicating no significant differences between the two.Conclusions : In Japan, normal-dose H2RA is expected to be a new PU preventive treatment strategy in patients requiring long-term NSAID therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02477.x
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  • 4
    Electronic Resource
    Electronic Resource
    Validity of 13C-phenylalanine breath test to evaluate functional capacity of hepatocyte in patients with liver cirrhosis and acute hepatitis (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : No definitive method for quantitative evaluation of hepatic function has as yet been established.Aim : To investigate whether the 13C-phenylalanine breath test would be useful for the evaluation of hepatic function in patients with liver cirrhosis and acute hepatitis.Methods : l-[1-13C]-phenylalanine was administered orally in a dose of 100 mg to 25 patients with liver cirrhosis, 22 patients with acute hepatitis and 10 healthy subjects. The relationships of the cumulative excretion with the 13C-%dose/h, blood biochemical parameters and asialoscintigraphy were investigated.Results : In liver cirrhosis patients, the cumulative excretion showed correlations with hepatic function tests, asialoscintigraphy, clinical stage and portal hypertension. In acute hepatitis patients, the cumulative excretion showed correlations with hepatic function tests. There were positive correlations between the cumulative excretion and the 13C-%dose/h at 20 min (Phe20) and 13C-%dose/h at 30 min (Phe30) in liver cirrhosis and acute hepatitis patients. Multiple regression analysis demonstrated that total bilirubin, total cholesterol and absence of varices were independent determinants of cumulative excretion in liver cirrhosis patients and prothrombin time in acute hepatitis patients.Conclusion : The 13C-phenylalanine breath test may allow hepatic function to be evaluated non-invasively in liver cirrhosis and acute hepatitis patients, and the Phe20 and Phe30 may be useful for determination of function at a single time-point.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02409.x
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for Involvement of p59fyn in Fasting-Induced Thymic Involution (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: p59fyn, a member of the src-family protein tyrosine kinase, is expressed abundantly in thymus. We examined the possible involvement of p59fyn in thymic involution induced by a fasting stress in Fyn–/– mice. An acute 48 h fast resulted in severe atrophy of the thymus and a marked decrease of the total thymocyte number with depletion of the CD4+CD8+[double positive (DP)] population in Fyn+/+ (control) mice. A remarkable increase in terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling-positive signals was detected in the fasted group of control mice. However, these findings were not observed in Fyn–/– mice. Interestingly, MRL/MPJ-lpr/lpr, a Fas-deficient model animal, also showed no significant decrease of DP cell numbers in the fasted group. p59fyn is known to interact with Fas signalling, and these findings suggest that p59fyn is involved in fasting-induced thymic involution, raising the possibility that Fas/p59fyn-mediated signalling may, at least partially, be associated with the phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01646.x
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  • 6
    Electronic Resource
    Electronic Resource
    The induced oxidation of cobalt(II) mesoporphyrin IX dimethyl ester by unsaturated hydrocarbons (1968)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 2723-2724 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01012a064
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    On precipitation of metastable centres in solid solutions NaCl–CaCl2 (1954)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 7 (1954), S. 514-515 
    Details
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0365110X54001636
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  • 8
    Electronic Resource
    Electronic Resource
    On precipitation of metastable centres in solid solutions NaCl–CaCl2 (1954)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 7 (1954), S. 514-515 
    Details
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0365110X54001636
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    A case of juvenile lipidosis: Electron microscopic, histochemical and biochemical studies (1968)
    Springer
    Acta neuropathologica 11 (1968), S. 122-139 
    Details
    ISSN: 1432-0533
    Keywords: Juvenile Lipidosis ; Electron Microscopy ; Histochemistry ; Biochemistry ; Granular Lipid Inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Elektronenmikroskopische, histochemische und biochemische Untersuchungen eines Falles von juveniler Lipidose werden mitgeteilt. Die neuronalen Einschlüsse sind zumeist von einer unit membrane umgeben und zeigen fingerabdruckähnliche Muster. Membranovesiculäre Körperchen finden sich ebenfalls in den Nervenzellperikaryen; typische granuläre Lipofuscinkörperchen werden aber nicht gesehen. Die Astrocyten der Rinde enthalten eine ähnliche Art von Einschlüssen, von denen aber die Einschlüsse in den Astrocyten der Marksubstanz völlig verschieden sind. Die Lokalisation der Aktivität von saurer Phosphatase in allen Einschlußtypen läßt an ihre mögliche lysosomale Natur denken. Die biochemische Analyse deckt keine spezifischen Abweichungen auf.
    Notes: Summary Electron microscopic, histochemical and biochemical studies of a case of juvenile lipidosis have been presented. The neuronal inclusions were mostly unit membranebound with fingerprint-like patterns. Membrano-vesicular bodies were also found in the neuronal perikarya, but “typical” granular lipofuscin bodies were not seen. Cortical astrocytes contained a similar type of inclusion but the inclusions in the astrocytes in the white matter were quite different. The localization of acid phosphatase activity in all types of inclusions suggests their possible lysosomal nature. Biochemical analysis failed to pin-point any specific abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690216
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  • 10
    Electronic Resource
    Electronic Resource
    Addition of Surface Function to Zirconia for Biomaterial Use (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 57 (Sept. 2008), p. 139-143 
    Details
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: Due to the merits of zirconia ceramics such as high strength, toughness, and abrasionresistance, as well as chemical stability in vivo, yttria-stabilized tetragonal zirconia polycrystals(Y-TZP) are currently used in the femoral head of hip prostheses. However, this material has a limitedrange of use because it is a bioinert material that does not interact with bone tissue and thus does noteasily integrate directly with bone. Therefore, addition of a material surface that enables the in vivoformation of a bone-like apatite layer that exhibits bioactivity and facilitates interactions andintegration with bone tissue is desired. In addition, by developing a surface structure that enhancesmechanical bonding, this material can be expected to be used as an alternative aggregate under loadbearing conditions. In the present study, structural design of the material surface, addition ofbioactivity using reagents treatment, confirmation of formation of the apatite layer using immersion insimulated body fluid, mechanical assessment, and wettability testing were conducted with theobjective of controlling interactions between zirconia ceramics and the body
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.57.139.pdf
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