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  • 1
    Electronic Resource
    Electronic Resource
    Chemistry of 9-diazoxanthene and 9-xanthylidene (1979)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 101 (1979), S. 3906-3916 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00508a031
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reinvestigation and reevaluation of addition and insertion reactions of 9-diazoxanthene and 9-xanthylidene (1978)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 100 (1978), S. 2922-2923 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00477a074
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The synthesis of 6'-deoxyhomonucleoside 6'-phosphonic acids (1968)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 90 (1968), S. 5337-5338 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01021a086
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  • 4
    Electronic Resource
    Electronic Resource
    The control of chiasma distribution in rye (1967)
    Springer
    Chromosoma 22 (1967), S. 69-90 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The chiasma conditions have been extensively analysed in two contrasting rye genotypes, one showing a normal and regular pattern of chiasma distribution and the other showing a highly abnormal and asymmetrical pattern of chiasma distribution. The analyses show that the pattern of chiasma distribution in the abnormal genotype conforms to the statistical expectations of randomness, and this is interpreted as being due to a breakdown of the processes which govern the distribution of chiasmata in normal rye genotypes. On the basis of these findings it is proposed that two independent and fundamentally different control systems are involved in the maintenance of efficient chiasma conditions in rye. One of these controls simply gives competence for chiasma formation, the other control system is evidently concerned with regulating the distribution of chiasmata. Analysis of two trisomic genotypes reveals that the conclusions relating to large samples of bivalents are also applicable to particular identifiable chromosomes. The results of brceding tests involving the two contrasting genotypes show that the control of chiasma distribution in rye has a complex genetic basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291287
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  • 5
    Electronic Resource
    Electronic Resource
    Further correlations between chiasmata and U-type exchanges in rye meiosis (1969)
    Springer
    Chromosoma 26 (1969), S. 105-118 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Earlier studies have demonstrated convincing correlations between the distribution patterns of chiasmata and of U-type exchanges within bivalents. On the basis of this evidence and other considerations it has been proposed that these contrasting meiotic exchange events are related in origin, and that U-type exchanges, giving rise to bridge and fragment configurations, arise as errors in crossing-over and chiasma formation. This hypothesis is given further consideration in the present report and further correlated distributions of chiasmata and U-type exchanges are presented. These correlations involve the distribution patterns of exchanges between bivalents and between the two arns of one particular bivalent which is consistently marked by the presence of localised neocentric activity. The relationships of these exchange distributions to chromosome length are also investigated and as a result it becomes clear that a mutual dependence of the two types of exchange on chromosome length cannot account for the observed correlations. The total evidence relating to the hypothesis of a causal connection between chiasmata and U-type exchanges is reviewed and critically assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319501
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  • 6
    Electronic Resource
    Electronic Resource
    Male and female meiosis in grasshoppers II. Chorthippus brunneus (1975)
    Springer
    Chromosoma 51 (1975), S. 381-389 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The frequencies and distribution patterns of chiasmata in the autosomal bivalents of Chorthippus brunneus are very similar in male and female meiosis. The mean cell chiasma frequency of oocytes is however significantly higher than that of spermatocytes, but this difference is almost certainly due to the incremental effect of the X bivalent on the chiasma frequencies of oocytes. The implications of these findings in terms of chiasma control are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326324
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of exchanges in differentially stained meiotic chromosomes of Locusta migratoria after BrdU-substitution and FPG staining (1978)
    Springer
    Chromosoma 69 (1978), S. 163-178 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Differential staining of the sister-chromatids of meiotic chromosomes of Locusta migratoria was achieved following abdominal implantation of BrdU tablets and fluorescent plus Giemsa (FPG) staining of fixed and squashed testicular follicles. This paper presents a detailed analysis of crossover exchanges between light and dark chromatids in monochiasmate bivalents. Approximately half the bivalents studied had visible exchanges of dark and light chromatids associated with the chiasmata, as expected if chiasmata originate by breakage and rejoining exchange events between randomly selected non-sister chromatids. In all the bivalents studied the visible crossover exchanges coincided exactly with chiasmata thus showing that chiasma movement (terminalisation) does not occur subsequent to crossing-over in Locusta migratoria, and that chiasmata are therefore accurate indicators of crossing over. It was noted that a proportion (9.5%) of chiasmata were associated with apparently anomalous exchanges of dark and light chromatids which could not be explained by conventional crossing-over. Various hypotheses for the origin of these anomalous exchanges are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329915
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  • 8
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of beta-methyl digoxin compared with digoxin tablets and capsules (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 231-236 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; beta-methyl-digoxin ; capsules ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intestinal absorption and urinary elimination rate of total cardioactive material was compared following digoxin and beta-methyldigoxin (BMD) administration to twelve healthy volunteers. Significantly more injected digoxin was recovered in urine. Urinary clearance was more rapid for digoxin, mean half-lives of elimination being 35 hours for digoxin and 40 hours for BMD. Calculated percentage intestinal absorption was lowest for digoxin tablets with a dissolution rate of 77% in one hour, intermediate for BMD tablets, and maximal for an experimental soft gelatin formulation of digoxin in solution. Respective mean values were 75%, 87% and 97%. Similar steady state plasma concentrations followed twice daily ingestion of the 0.25 mg digoxin tablets and 0.20 mg BMD tablets. Mean peak plasma concentration and percentage urinary recovery of ingested dose were higher during continued BMD administration. Between-subject variation in absorption was higher for the digoxin tablets. The comparative intestinal absorption of BMD and digoxin depends upon the formulation. Digoxin is virtually completely absorbed from a solution encapsulated in soft gelatin. Relatively more BMD is eliminated by nonrenal routes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558334
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  • 9
    Electronic Resource
    Electronic Resource
    Phosphorus-nitrogen compounds. 22. Synthesis and antitumor activity of arylsulfonylhydrazones (1978)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 21 (1978), S. 1146-1149 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00209a011
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Nuclear Variation between Diploid Angiosperms (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 828-830 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EXTENSIVE polyploid series in many plant genera, particularly in Angiosperms, testify to the prominence and importance of quantitative variation in nuclear genetic material during the evolution and divergence of numerous species. In sharp contrast, but not uncommonly, are other plant genera which ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211828a0
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