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  • 1960-1964  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Cardiovascular lesions in Swiss mice fed a high fat  -  Low protein diet with and without betaine supplementationSupported by grant H-4052 (C2) from the National Institutes of Health, U.S.P.H.S. (1963)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 145 (1963), S. 49-59 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Young adult mice of an albino stock (Taconic Swiss) were fed a hypolipotropic diet with a fat content (lard) of 28% and 8% protein (casien). The same diet containing betaine hydrochloride (2%) as a lipotropic supplement was fed to one-half the mice.After seven weeks of restriction to these diets (with and without betaine supplementation) pronounced lesions had developed in the hearts. These lesions consisted of myocardial necrosis and thrombi within atrial lumina. The thrombi increased progressively in size, reaching critical and lethal dimensions for 75% of the animals by 13 weeks. Atrial dilatation, as a compensating mechanism, was a typical response. Small foci of myocardial necrosis with calcification and fibrosis were common in the ventricles. All mice surviving for longer than 13 weeks showed the myocardial changes ventricles. All mice surviving for longer than 13 weeks showed the myocardial changes and the thrombosis described above. Mural necrosis was observed in the intramyocardial branches of coronary arteries but thrombosis was infreqent within these vessels. There was extreme weight loss which paralleled the onset and increasing severity of the cardiac lesions. Betaine, as a dietary lipotrope, did not prevent or alter the cardiovascular lesions.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091450108
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Actions of betaine, carnitine and choline on the pattern of hepatic liposis in mice fed a high-fat, low-protein dietSupported by grant HE-07318 from the National Institutes of Health, U.S.P.H.S. (1964)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 149 (1964), S. 677-689 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Four stocks (C, C-57 Bl, DBA and Swiss albino) of mice were fed a high-fat (28%), low-protein (8%), hypolipotropic diet for 3-480 days. Lipotropic activities of supplements of betaine and carnitine were evaluated. There were no strain-limited hepatic responses to the diet or to the action of the lipotropes. Without lipotropic supplements, parenchymal liposis (sudanophilia of frozen sections) was progressively incremental in all lobular zones for approximately 90 days. Subsquently, lobular liposis decreased and the remaining fat was concentrated in the middle zone within cords of fat-laden cells radiating in a stellate pattern. With choline supplemention, liposis was limited to small amounts of fat within cells that composed the stellate pattern. Betaine displayed a level of lipotropic activity approximating one-half to three-fourths that of choline. The lipotropic activity of carnitine was marginal and inconsistent. The combination of betaine and carnitine demonstrated some synergistic action. No parenchymal hyperplasia was observed. The intralobular reticulum increased in some livers, primarily around the central and intercalated veins, but no lobular distortion resulted.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091490411
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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