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  • 1
    Digitale Medien
    Digitale Medien
    Atopic dermatitis and congenital deafness (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In a family with perceptive, non-progressive hearing loss several of the members suffered from atopic dermatitis. The proband had a severe atopic dermatitis and an extremely high IgE value. Some of the family members suffered from atopic dermatitis, others from deafness, and some from both diseases. The co-existence of these two disorders has been previously described in two families. Atopic dermatitis and perceptive, non-progressive congenital deafness might be genetically associated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb02004.x
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  • 2
    Digitale Medien
    Digitale Medien
    Allergic contact dermatitis from croton (Codiaeum) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 3 (1977), S. 0 
    Details
    ISSN: 1600-0536
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0536.1977.tb03609.x
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  • 3
    Digitale Medien
    Digitale Medien
    Contractile responses to direct stimulation of frog slow muscle fibres before and after denervation (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 43-50 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Slow fibres ; Contractile responses ; Effect of denervation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract 1. The contractile responses of single slow muscle fibres were investigated under isometric conditions. The fibres were isolated from normal and denervated iliofibularis muscles ofRana temporaria. Direct stimulation was achieved by external application of electrical pulses or depolarizing solutions (40 mM K and acetylcholine 10\t-6 g/ml). 2. Upon electrical stimulation normal slow fibres developed contractions whose amplitude increased steadily with the strength of the pulses. These contractions did not exceed 0.22 kg/cm2, and their rates of rise and fall were approximately 1/6 of those observed in twitch fibres. During pulses of several 100 ms duration the tension continued to rise slowly until the end of the pulses. Application of 40 mM K or acetylcholine resulted in contractures which reached maximum values of 1.71 and 1.87 kg/cm2, respectively, after less than 1 min; little relaxation occurred during the following minutes. 3. The responses of slow fibres denervated for 9−76 days differed in several respects from those of normal slow fibres. a) The contractions elicited by electrical stimulation became faster but their amplitude decreased; the relationship between tension and pulse strength remained, however, essentially unchanged. b) Small and short contractions could be observed during and at the end of stimulating current pulses. Their amplitude was independent of the amplitude and duration of the stimuli; they were blocked by tetrodotoxin and must be attributed to action potentials. c) The ability to develop and maintain tension was reduced. Maximum values of K- and acetylcholine contractures were generally only 50% of those observed in normal slow fibres. Maintenance of tension was markedly reduced in some fibres, less so in others. 4. It is concluded that incorporation of Na channels into its membrane does not transform the slow fibre into a type of fibre which resembles a twitch fibre.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00585902
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of nerve length and temperature on the induction of action potentials in denervated slow muscle fibres of the frog (1977)
    Springer
    Pflügers Archiv 372 (1977), S. 17-22 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Slow muscle fibres ; Action potential ; Nerve stump ; Temperature
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A. Pyriformis and extensor longus digiti IV muscles of Rana temporaria were denervated by cutting the sciatic or peroneal nerve at various distances from the muscles. Slow fibres were identified by their membrane time constants, and examined for their ability to produce action potentials in response to intracellularly applied current pulses. B. The slow muscle fibres acquired the ability to generate action potentials several days after denervation. The duration of this latent period depended on the length of the peripheral nerve stump, and on the temperature at which the frogs were kept after the operation. C. At 18°C the latent period increased by 0.36 days per mm of sciatic nerve stump. At 11.5° C the corresponding value was 0.7 days/mm. The effect of length of the peroneal nerve was smaller than that of the sciatic nerve. D. It is suggested that the peripheral nerve stump serves as a reservoir of ‘trophic’ material which is transported towards the slow fibres at a rate of 2.8 mm/day (at 18° C) and seems to block the formation of Na channels. TheQ 10 value of this transport system would be 2.7.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00582201
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  • 5
    Digitale Medien
    Digitale Medien
    Changes in envelope permeability during chloroplast development (1976)
    Springer
    Planta 129 (1976), S. 69-73 
    Details
    ISSN: 1432-2048
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The permeability of the plastid envelope during the development of Avena sativa plastids was investigated by light scattering and uptake of various labelled compounds (malate, succinate, glutamate, α-ketoglutarate, citrate, glycine, sucrose). The results presented show that a primary event during greening is a change in permeability, thereby allowing an increased transport of metabolites across the membranes of very early etio-chloroplast stages. The results are discussed in view of an adaption of the plastid envelope permeability to the changing requirements of externally synthesized precursors and intermediates during development.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00390916
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  • 6
    Digitale Medien
    Digitale Medien
    Analgetika und Darmmotorik (1953)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 219 (1953), S. 302-309 
    Details
    ISSN: 1432-1912
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Zusammenfassung 1. Am isolierten Dünndarm des Meerschweinchens in einer modifizierten Versuchsanordnung nach Trendelenburg wird eine durch Acetylcholin oder Histamin bewirkte Kontraktion der Längsmuskulatur durch eine durch Erhöhung des Innendruckes ausgelöste peristaltische Welle der Ringmuskulatur gelöst, um nach Sistieren der Peristaltik wiederzukehren. Dies spricht für eine aktive, adrenerg hemmende Rückwirkung der Ringmuskelkontraktion auf die Längsmuskulatur. 2. Morphin verhindert schon in kleinsten Dosen die durch Temperaturreize verursachte Tonuserhöhung der Längsmuskulatur. 3. Die nach Auslöschung der Peristaltik durch kleine Cocaindosen verbleibende druckbedingte Tonuserhöhung der Längsmuskulatur wird durch Morphin aufgehoben.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00246405
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  • 7
    Digitale Medien
    Digitale Medien
    Referatenteil (1954)
    Springer
    Journal of molecular medicine 32 (1954), S. 274-285 
    Details
    ISSN: 1432-1440
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01466823
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  • 8
    Digitale Medien
    Digitale Medien
    Referatenteil (1954)
    Springer
    Journal of molecular medicine 32 (1954), S. 568-574 
    Details
    ISSN: 1432-1440
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01484948
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  • 9
    Digitale Medien
    Digitale Medien
    Cyclophosphamide-resistant Yoshida ascites tumor cells and their cross resistance to some alkylating agents (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 257-263 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Yoshida ascites tumor ; Cyclophosphamide ; Alkylating agents ; Resistance and cross resistance
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A cyclophosphamide-resistant subline of a Yoshida ascites tumor was developed by giving increasing doses of the drug after transplantation. The effect of several alkylating agents on the cell proliferation of both the sensitive and resistant cell line was compared establishing dose response curves and D50 values. The developed subline revealed a 260 fold resistance to cyclophosphamide. It was completely cross-resistant to hydroperoxycyclophosphamide, whereas for triaziquone, N-oxide-mustard, and N-methyl-mustard only a partial cross resistance existed. These results give further evidence that cyclophosphamide and hydroperoxycyclophosphamide have the same mechanism of action. Regarding the other alkylating agents the results demonstrate differences concerning either the molecular mode of action or protecting effects. A decreased activation or uptake of substance is probably not the base for resistance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00419285
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  • 10
    Digitale Medien
    Digitale Medien
    Besprechungen (1954)
    Springer
    Naturwissenschaften 41 (1954), S. 581-584 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00584179
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