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  • 1
    Digitale Medien
    Digitale Medien
    The efficacy of histopathological criteria required for diagnosing dysplastic naevi (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 12 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The efficacy of specific histopathological features for diagnosing dysplastic naevi was established by comparing their frequency in 62 dysplastic naevi, from 36 patients with the dysplastic naevus syndrome, with those in 326 ostensibly benign naevocellular naevi derived from a group of 67 autopsy cases. Individual diagnostic features had a low sensitivity, a low specificity or low predictive values. Discriminant analysis showed that the presence of dust-like melanin, irregular naevoid nests, markedly increased junctional activity and melanocytic nuclei equal or larger in size than overlying keratinocyte nuclei were the most discriminating features. Using two or more of these criteria plus a lymphocytic infiltrate as an obligatory diagnostic criterion, a reasonable efficacy could be reached for dysplastic naevi. Based on these combinations of criteria the prevalence of histologically proven dysplastic naevi in the autopsy group would be 10%. Lesions with all these four discriminating features were found in half of the patients from the dysplastic naevus syndrome group, but were absent in the autopsy group. We suggest that such severely atypical dysplastic naevi may be indicative of patients at high risk for developing malignant melanoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb01943.x
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  • 2
    Digitale Medien
    Digitale Medien
    The splenic red pulp; a histomorphometrical study in splenectomy specimens embedded in methylmethacrylate (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The anatomy and pathology of the splenic red pulp was studied in three-dimensional reconstructions of methylmethacrylate embedded blocks of tissue obtained after splenectomy, as well as by morphometrical analysis of a large number of specimens. The sinuses of the spleen form a plexus of anastomosing vessels with remarkable buds. Capillaries end as sheathed capillaries in the cord tissue, the ‘filtering’ area, but a large proportion of the red pulp cords appear to be ‘non-filtering’. These might form part of the lymphatic compartment, which is separate from the white pulp and its extension along the capillaries. This area has not yet been described in man. The change in the volume and structure of the various components of the red pulp were studied in 60 controls and in cases of traumatic rupture, idiopathic thrombocytopenic purpura, aplastic anaemia, autoimmune haemolytic anaemia, congenital spherocytosis, splenic congestion, and Hodgkin's disease. Significant differences were found in the volume of filtering and non-filtering areas, the size of the sinus compartment, and the degree of vascularization; these differences were only partially expected, for instance in disorders with excessive erythrocyte sequestration. A decrease of the ‘non-filtering’ area in Hodgkin's disease might indicate an unknown aspect of this disease. In agreement with our previous paper on the amount of white pulp, spleens removed because of traumatic rupture and those incidentally removed during abdominal surgery may not be combined as a single control group, because of significant and probably functional differences in the composition also of the red pulp.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02824.x
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  • 3
    Digitale Medien
    Digitale Medien
    Cyanoacrylate skin surface stripping: an improved approach for distinguishing dysplastic nevi from malignant melanomas (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 16 (1989), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We present a novel approach for improving the management of patients with pigmented neoplasms including malignant melanomas and dysplastic nevi. A cohort of 215 dysplastic nevi and malignant melanomas was studied by cyanoacrylate skin surface stripping (CSSS) and conventional histology. Presence of atypical melanocytes was found in the stratum corneum in more than 95% of malignant melanomas and was always absent in dysplastic nevi. We conclude that this non-invasive technique is rapid, easy to perform, and inexpensive. Its specificity and sensitivity are high enough to be considered by clinicians as an aid for distinguishing dysplastic nevi from malignant melanomas. We recommend this ancillary technique as a screening procedure though not as a substitute for conservative excisional biopsy, when doubt persists in the diagnosis of atypical pigmented neoplasms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0560.1989.tb00037.x
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  • 4
    Digitale Medien
    Digitale Medien
    Variations in histopathological evaluation of nonneoplastic colonic mucosal abnormalities; assessment and clinical significance (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The variation between three pathologists examining histological features seen in non-neoplastic colonic mucosa from 40 biopsies was analysed. Several procedures to express observer variation were used and compared, with emphasis on kappa statistics. Only five features, the presence of ulceration, villous surface, epithelioid granulomas, severe mucus depletion and crypt abscesses were sufficiently reproducible by the three pairs of pathologists. These findings suggest that other criteria used for the classification of inflammatory bowel disease are potentially unsatisfactory. When results from different studies on biopsies are being compared, influence of observer variation should be identified. Comparison of statistical techniques showed overall variation to be less useful than other statistical procedures. There was little difference between results from kappa statistics and other measures of agreement (overall agreement excluded).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1985.tb02834.x
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  • 5
    Digitale Medien
    Digitale Medien
    Über Dichte und Lichtbrechungsvermögen von Zellulosefasern (1944)
    Springer
    Colloid & polymer science 109 (1944), S. 9-16 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01815147
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  • 6
    Digitale Medien
    Digitale Medien
    Beiträge zur Theorie der Viskosität der Lösungen makromolekularer Substanzen (1943)
    Springer
    Colloid & polymer science 105 (1943), S. 199-204 
    Details
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Notizen: Zusammenfassung Es werden einige Gesichtspunkte zum Verständnis der Viskosität von Lösungen makromolekularer Substanzen hervorgehoben, die, wie es uns scheint, bis heute ungenügend beachtet wurden. Die bisherigen Theorien der Viskosität extrem verdünnter Lösungen haben entweder starre anisodiametrische Teilchen oder starre Molekülknäuel vorausgesetzt. Es scheint uns wahrscheinlicher, da\ die Knäuel im Strömungsgefälle dauernd deformiert werden und gleichzeitig wieder in ihre wahrscheinlichste Gestalt zurückzukehren bestrebt sind. Das Produkt des Schubmoduls, den man der bei der Knäueldeformation erzeugten Spannung zuordnen kann, und der Relaxationszeit dieser Deformation liefert einen Beitrag zur Viskosität, der — wie in der nächsten Abhandlung gezeigt wird — den Beobachtungen quantitativ gerecht wird. Es wird weiter darauf hingewiesen, da\ unter den Wechselwirkungen zwischen den gelösten Molekülen, die dauernd wechselnden Assoziationsbindungen zwischen den Ketten eine wichtige Rolle spielen dürften. Diese Assoziationen finden an lokalen Verklebungsstellen (Haftpunkten) statt und stellen (im Kuhnschen Sinne) einen Zusammenhaltsmechanismus mit beschränkter Lebensdauer dar, der erheblich zur Viskosität beitragen kann (vgl. auch die dritte Arbeit dieser Serie). Diesen Betrachtungen kommt auch für das Verständnis der Gelbildung und Gelstruktur Bedeutung zu. Es wird gezeigt, da\ mehrere, bis jetzt wenig beachtete Erscheinungen, in dieser Weise gedeutet werden können.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01522087
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  • 7
    Digitale Medien
    Digitale Medien
    Magnetic resonance imaging in the diagnosis and staging of renal masses: a critical appraisal and comparison with computed tomography (1988)
    Springer
    World journal of urology 6 (1988), S. 35-43 
    Details
    ISSN: 1433-8726
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The purpose of this prospective study was to compare the accuracy of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis and staging of renal masses. MRI was performed with an 0.5 T superconducting MR-scanner using conventional T1- and T2-weighted spin-echo pulse sequences. The results of MRI and CT were compared in 31 patients with a renal mass. In the diagnosis of benign tumors, similar information was obtained by MRI and CT. Regarding malignant tumors, one transitional cell carcinoma, imaged by CT, was not shown by MRI. CT appeared to be slightly more accurate in the determination of perinephric extension of renal cell carcinoma (stage I vs stage II). Similar results were obtained in stage III and stage IV tumors. The main diagnostic limitations which may lead to inaccurate staging of renal cell carcinoma are encountered in MRI as well as CT. They are: the assessment of tumor extension into the intrarenal vein, the differentiation between lymphadenopathy due to reactive hyperplasia and metastatic involvement and the differentiation between tumor extension into adjacent organs and adhesions without tumor spread outside the renal capsule. It is concluded that CT remains the method of choice in the diagnosis and staging of renal masses as long as no substantial improvements in MRI performance have been achieved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00326841
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  • 8
    Digitale Medien
    Digitale Medien
    Isolation and characterization of Methanoplanus endosymbiosus sp. nov., an endosymbiont of the marine sapropelic ciliate Metopus contortus quennerstedt (1986)
    Springer
    Archives of microbiology 144 (1986), S. 367-374 
    Details
    ISSN: 1432-072X
    Schlagwort(e): Ciliate culture ; Endosymbiosis ; Interspecies hydrogen transfer ; Hydrogenosome ; Methanogenic bacteria ; Methanoplanus endosymbiosus sp. nov. ; Metopus contortus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Epifluorescence microscopy revealed the presence of a methanogenic bacterium as an endosymbiont in the sapropelic marine ciliate Metopus contortus. The in situ methanogenic activity of the symbiont could be demonstrated. The isolated endosymbiont was an irregular, disc-shaped bacterium with a diameter of 1.6–3.4 μm. It had a generation time of 7 or 12 hours on growth on H2/CO2 or formate, respectively. The temperature range for growth was between 16 and 36°C with an optimum at 32°C. The optimal pH range for growth was 6.8 to 7.3. Salts, with an optimum concentration of 0.25 M, and tungsten were required for growth. The mol% G+C was 38.7%. The cell envelope consisted of proteins and a glycoprotein with an apparent molecular weight of 110,000. Morphology, antigenic relationship and the G+C content established the isolate MC1 as a new species of the genus Methanoplanus, and the name Methanoplanus endosymbiosus is proposed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00409886
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  • 9
    Digitale Medien
    Digitale Medien
    Nucleotide sequence of cDNA clones encoding the complete precursor for subunit delta of thylakoid-located ATP synthase from spinach (1988)
    Springer
    Plant molecular biology 10 (1988), S. 323-330 
    Details
    ISSN: 1573-5028
    Schlagwort(e): chloroplast ATP synthase ; subunit delta ; cDNA nucleotide sequence ; transit peptide ; spinach
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The nucleotide sequence of the entire nuclear-encoded precursor for subunit delta of the ATP synthase from spinach thylakoid membranes was determined by cDNA sequencing. Appropriate recombinant DNAs were selected from pBR322 and lambda gt11 libraries made from polyadenylated RNA of greening spinach seedlings. The mature protein consists of 187 amino acid residues corresponding to a molecular weight of 20468. The precursor protein (257 amino acid residues; M r=27676) is probably processed between a Met-Val bond. The predicted secondary structure of the transit sequence (70 residues; 7.2 kDa) resembles that of the Rieske Fe/S polypeptide, but shows little similarity with those of stromal or luminal proteins. The comparison of the chloroplast delta amino acid sequence with the published delta sequences from respiratory ATP synthases of bacterial and mitochondrial sources and from the thylakoid ATP synthase of the cyanobacterium Synechococcus suggests substantial divergence at the genic level although structural elements appear to be remarkably conserved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00029882
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  • 10
    Digitale Medien
    Digitale Medien
    Das Diffusionspotential in Elektrolytlösungen (1943)
    Springer
    Naturwissenschaften 31 (1943), S. 257-260 
    Details
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01475682
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