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  • 1
    Electronic Resource
    Electronic Resource
    DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 348-353 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00167a045
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  • 2
    Electronic Resource
    Electronic Resource
    Über kupferhaltige Gemüsekonserven und die Bestimmung ihres Kupfergehaltes (1909)
    Springer
    European food research and technology 18 (1909), S. 538-550 
    Details
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02003679
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  • 3
    Electronic Resource
    Electronic Resource
    Serumspiegel und organablagerungen vonΒ 2-mikroglobulin bei dialysepatienten (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1150-1155 
    Details
    ISSN: 1432-1440
    Keywords: Β 2-Mikroglobulin ; AB-Amyloid ; Dialysis ; Arthropathy ; Spondylarthropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In radioimmunological estimation ofΒ 2-microglobulin (Β 2m) significant higher serum values were found in 36 dialysis patients (44.4±20.3 mg/l) in comparison with healthy probands (1.5±0.2 mg/l). A significant relation to the duration of dialysis, diuresis, symptoms of the musculo-skeletal system, but not to radiologic changes or bone biopsy findings could be seen. Post mortem examinations carried out in 21 dialysis patients revealed AB-amyloid depositis in synovial tissue of different joints (particularly shoulder and hip joint) or intervertebral discs in eight patients (age 48 to 73 years, dialysis duration less than four years) without correlation to serumΒ 2m level or radiographically suspect areas. In the tissue of cervical spine or intervertebral discs of two patients suffering from destructive spondylarthropathy no amyloid could be detected. These results suggest that AB-amyloid may occur in elderly patients early in the course of hemodialysis and may be asymptomatic in most cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01798067
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  • 4
    Electronic Resource
    Electronic Resource
    Responsiveness of gene expression markers of osteoblastic and osteoclastic activity to calcitonin in the appendicular and axial skeleton of the rat in vivo (1994)
    Springer
    Calcified tissue international 54 (1994), S. 511-515 
    Details
    ISSN: 1432-0827
    Keywords: Collagen ; Osteocalcin ; Bone mineral density ; Skeletal heterogeneity ; TRAP ; Cell proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We have previously shown that calcitonin (CT), an inhibitor of bone resorption, increases vertebral, but not femoral bone density in the rat [3]. To address the physiologic responses associated with these effects on bone mineral density (BMD), we assessed mRNA transcripts reflecting activities of osteoblasts (type I collagen, osteocalcin, osteopontin, and alkaline phosphatase), osteoclasts [tartrate-resistant acid phosphatase (TRAP)], and cell proliferation (histone H4) in the spine and femur of these rats. CT increased spine BMD while increasing type I collagen and decreasing TRAP and histone mRNAs. In the femur, where CT had no effect on BMD, it decreased type I collagen and histone H4 mRNA but did not affect TRAP. CT had no effect on the gene expression of osteocalcin, osteopontin, or alkaline phosphatase at either site. The results indicate that selective alterations in gene expression, as reflected by steady state mRNA levels, are consistent with the changes observed by BMD measurement, and can more clearly define the specific contribution from osteoblast and osteoclast activity. This study demonstrates a heterogeneity in response of the axial and appendicular skeleton to CT, reflected by alterations in gene expression that provide a basis for understanding the observed BMD responses to various pharmacologic interventions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334334
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  • 5
    Electronic Resource
    Electronic Resource
    Do limited changes in phosphate intake modulate 1,25(OH)2D3 levels in early renal failure? (1992)
    Springer
    Pediatric nephrology 6 (1992), S. 564-564 
    Details
    ISSN: 1432-198X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866509
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  • 6
    Electronic Resource
    Electronic Resource
    Non-lectin component in a fermented extract from Viscum album L. grown on pines induces proliferation of lymphocytes from healthy and allergic individuals in vitro (1994)
    Springer
    European journal of clinical pharmacology 47 (1994), S. 33-38 
    Details
    ISSN: 1432-1041
    Keywords: Viscum album ; Iscador Pini ; Lactobacillus plantarum ; lectins ; mistletoe extracts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Mistletoe preparations have been shown to express immunomodulatory properties. In order to evaluate the stimulatory potency of different mistletoe extracts, peripheral blood mononuclear cells (PBMC) from healthy and allergic/atopic individuals were exposed to aqueous or fermented extracts derived from Viscum album L. grown on apple trees (Mali-extracts) or on pines (Pini-extracts). None of them had received any mistletoe treatment. Iscador Pini was the only extract which strongly induced proliferation of PBMC in contrast to the other five preparations. On testing these extracts by Western blotting with anti-mistletoe lectin-1 (ML-1) antibody positive sera from mistletoe-treated patients, it became evident that Iscador Pini was almost devoid of lectins. The stimulatory potency of Iscador Pini for PBMC from three different groups was examined: PBMC from 35 normal controls (Group I), 23 patients with drug-induced adverse effects (Group II) and 16 individuals with allergic manifestations (Group III). Cells were exposed in 7-day cultures to the extract at concentrations between 1 and 10,000 μg/ml. PBMC from 63% of Group III individuals showed strong stimulation (SI varying from 6 to 97) in contrast to only 9% from Group I and 22% from Group II individuals. Anti-ML-1 antibodies were detected in 5% and anti-IP antibodies in 11% of subjects in the three groups. They were either of the IgA or IgM type but not of the IgG type. Our findings strongly imply that a non-lectin associated antigen from Iscador Pini is able to activate PBMC from healthy and allergic/atopic individuals, thereby demonstrating sensitization to probably highly conserved plant antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00193475
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  • 7
    Electronic Resource
    Electronic Resource
    Treatment of acute uncomplicated urinary tract infection with ceftibuten (1991)
    Springer
    Infection 19 (1991), S. 124-126 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ceftibuten ist ein Oralcephalosporin der dritten Generation mit erhöhter Aktivität gegenEnterobacteriaceae-Arten. Die Wirksamkeit und Sicherheit dieses neuen Antibiotikums wurden in einer offenen Studie bei 74 Frauen mit akuter, unkomplizierter Harnwegsinfektion geprüft. Die Patientinnen erhielten sieben Tage lang eine einmal tägliche Dosis von 400 mg Ceftibuten oral. Nach Ende der Therapie wurden vier bis sechs Wochen lang Nachuntersuchungen vorgenommen. In allen Fällen war eine Erregereradikation nachzuweisen, darunter waren auch fünf Fälle, bei denen koagulase-negative Staphylokokken mit Resistenz gegen Ceftibuten aus dem Urin isoliert worden waren. Eine Heilung war fünf bis neun Tage nach Behandlungsende bei 93% der Patientinnen eingetreten. Rezidive wurden in einem von fünf Fällen auf eine Reinfektion zurückgeführt, in vier Fällen durch den ursprünglichen Keim. Vier bis sechs Wochen nach Therapie hatten weitere fünf Patientinnen erneut Infektionsschübe entwickelt. Insgesamt kam es in dieser Studie zu einer Heilungsrate von 85%. Nebenwirkungen, die unter der Therapie mit Ceftibuten auftraten, waren meistens leicht und betrafen den Gastrointestinaltrakt. Die häufigste Nebenwirkung war Diarrhoe. Der Latex-Agglutinationstest fürClostridium difficile war in drei von acht Fällen mit Diarrhoe (11% des Gesamtkollektivs) positiv. Bei Frauen mit akuter, unkomplizierter Harnwegsinfektion erwies sich die Therapie mit Ceftibuten als wirksam und im allgemeinen sicher. Bedenken ergeben sich aus der hohen Diarrhoerate in dieser Studie.
    Notes: Summary Ceftibuten is an orally active third generation cephalosporin with increased potency against members of theEnterobacteriaceae. In this study, 74 women with acute uncomplicated urinary tract infection (UTI) were enrolled in an open study to evaluate the safety and efficacy of this new antibiotic. Patients were treated with 400 mg ceftibuten once daily for seven days and followed for four to six weeks after cessation of therapy. All pathogens were eradicated during treatment, including five coagulase-negative staphylococci that were resistant to ceftibuten. At five to nine days posttreatment, 93% of patients were cured. Of the five recurrent infections, four patients had a relapse and one had a reinfection. By four to six weeks post-treatment, five additional patients had recurrent infections. The overall cure rate was 85% in this study. Most ceftibuten-associated adverse effects were mild and involved the gastrointestinal tract. Diarrhea was the most commonly reported side effect. Of the eight (11%) patients who developed diarrhea, three had a positive latex agglutination test forClostridium difficile. The diarrhea resolved in all patients without sequelae. Ceftibuten was effective and generally safe in the treatment of women with acute uncomplicated UTI. The high incidence of diarrhea observed in this study is a concern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01645584
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative study of clarithromycin and penicillin V in the treatment of streptococcal pharyngitis (1991)
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 949-953 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study evaluated the safety and efficacy of clarithromycin in the treatment of patients with Group A beta-hemolytic streptococcal pharyngitis. Subjects were treated with either 250 mg clarithromycin twice daily or 250 mg penicillin V four times a day for 10 days and followed for approximately three weeks post-treatment. At the completion of therapy, 96 % (45/47) of patients treated with clarithromycin and 89 % (43/48) of patients treated with penicillin V were clinically cured or improved. Recurrence of symptoms occurred in 7 and 5 patients who were treated with clarithromycin and penicillin V respectively. Initial bacteriologic eradication was observed in all but one patient. Recurrence ofStreptococcus pyogenes occurred in 5 (11 %) patients who received clarithromycin and 7 (15 %) patients who received penicillin V. The majority of adverse events reported during this study were mild and involved the gastrointestinal tract. Diarrhea was more frequent in patients who received clarithromycin. In this multicenter, randomized, double-blind trial, clarithromycin was as safe and effective as penicillin V in the treatment ofStreptococcus pyogenes throat infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005450
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  • 9
    Electronic Resource
    Electronic Resource
    Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 53 (1993), S. 240-250 
    Details
    ISSN: 0730-2312
    Keywords: osteocalcin ; CCAAT ; transcription ; phosphatase ; steroid-like half-elements ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The rat osteocalcin gene encodes a 6-kD osteoblast-specific protein that is expressed postproliferatively. The developmental and steroid hormone responsive expression of the osteocalcin gene is transcriptionally regulated by a promoter with multiple basal and enhancer elements that exhibit activity controlled by a series of physiological mediators (e.g., 1,25(OH)2D3, glucocorticoids). In this study, we established the contribution of the rat osteocalcin (OC) box domain ( -99 to -76), a proximal basal element with a CCAAT motif as a central core, to transcriptional activity of the rat osteocalcin gene with in vivo co-transfection assays. By this same assay, however, the highly homologous (22 of 24 nt) human OC box element was unable to compete for transcription factor binding with the rat OC promoter. In vitro protein/DNA interaction studies confirm the presence of two protein binding sites in the OC box region, one of which overlaps the CCAAT motif and, at least in part, accounts for species-specific expression. Competition analysis established that the single nucleotide substitution of adenine for thymine, which converts the core motif of the rat OC box (CCAAT) to the core motif of the human OC box (CCAAA), accounts for observed species differences in transcription factor interactions. The CCAAT-specific protein/DNA interactions are heat stable and insensitive to phosphatase treatment. A second protein/DNA interaction located upstream of the CCAAT motif includes two steroid-like half-elements. These interactions are heat labile and sensitive to phosphatase treatment in contrast to the CCAAT-specific interactions. The human OC promoter contains only a single steroid-like half-element, while two steroid half-elements with an 11 nucleotide spacer are present in the rat OC promoter. These observed variations in sequence organization and transactivation factor binding in analogous proximal basal regulatory regions of the OC gene promoter may provide a basis for species-restricted variations in responsiveness to physiological mediators of OC gene expression at the transcriptional level.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240530309
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  • 10
    Electronic Resource
    Electronic Resource
    Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells (1994)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 55 (1994), S. 218-229 
    Details
    ISSN: 0730-2312
    Keywords: osteosarcoma cells ; osteocalcin gene ; osteoblasts ; vitamin D response element (VDRE) ; transcription factor complexes ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Vitamin D responsive transcription of the bone-specific osteocalcin gene differs markedly in osteosarcoma cells and normal diploid osteoblasts. In osteoblasts the osteocalcin gene is transcribed, and upregulated by Vitamin D, only in post-proliferative cells, but in osteosarcoma cells expression is constitutive. This distinction in transcriptional regulation of the osteocalcin gene correlates with striking differences in the relative representation of two principal Vitamin D-dependent protein/DNA complexes designated V1 and V2 at the Vitamin D responsive element in the osteocalcin promoter. Formation of both complexes is Vitamin D dependent and they contain the Vitamin D receptor as well as an RXR related protein. Pore size exclusion and sedimentation velocity analyses suggest that the V1 and V2 complexes represent oligomeric protein assemblies (respectively, tetramers and trimers), and reflect primarily DNA-directed association of the monomeric protein components at the osteocalcin Vitamin D responsive element. UV crosslinking and methylation interference analyses of the V1 and V2 complexes at the osteocalcin Vitamin D responsive element indicate differences in protein/DNA recognition. For example, the V1 complex interacts with both steroid half-elements, whereas the V2 complex appears to recognize the proximal half-element. Our findings suggest variations in protein/protein and protein/DNA interactions of the VDR and RXR related complexes V1 and V2 at the osteocalcin Vitamin D responsive element that reflect unique properties of the osteosarcoma and normal diploid osteoblast phenotype. © 1994 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240550209
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