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  • 1
    Electronic Resource
    Electronic Resource
    Histological observations on the failure of rachitic rat bones to respond to 1,25/OH)2D3 (1980)
    Springer
    Calcified tissue international 31 (1980), S. 215-223 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; 1,25(OH)2D3 ; 25OHD3 ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Rachitic rats, maintained on diets with low or normal P contents, were given daily intraperitoneal doses of 1,25(OH)2D3 or 25OHD3 at levels of 100 or 200 ng. Plasma chemistry was measured and the ash content and histological appearance of the bones investigated. Using labeled material it was shown that the dosing levels of 1,25(OH)2D3 employed ensured a higher than normal plasma concentration of that metabolite over the period between doses. 1,25(OH)2D3 was not as effective as 25OHD3 in raising bone ash or reducing the amount of osteoid. The difference between the effects of the metabolites was evident at both dietary P levels, but more marked at the higher P level. In contrast, the metabolites reduced the width of the epiphyseal plate to an approximately similar degree, and this is possibly the reason why there are discrepancies between previous reports of the effectiveness of 1,25(OH)2D3 compared with 25OHD3 or vitamin D3. Dosing with 1,25(OH)2D3 failed to maintain a constant plasma Pi value over the period between doses in animals fed the low P diet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02407184
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Central Modulation of Rectal Distension-Induced Blood Pressure Changes by Alosetron, A 5-HT3 Receptor Antagonist (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 20-24 
    Details
    ISSN: 1573-2568
    Keywords: ALOSETRON ; 5-HT3 RECEPTOR ANTAGONIST ; IRRITABLE BOWEL SYNDROME ; VISCERAL NOCICEPTION ; RECTAL DISTENSION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Irritable bowel syndrome (IBS) represents one ofthe most common gastrointestinal-related diagnoses.Although the precise etiologic basis of IBS is notknown, a common presenting symptom is abdominal pain or discomfort that is thought to develop, atleast in part, from a heightened awareness of visceralnociceptive input. Agents capable of reducing thisheightened visceral nociception would, therefore, have utility in the treatment of IBS. In this studywe evaluated the effects of intravenous andintracerebroventricular administration of a5-HT3 receptor antagonist, alosetron, onblood pressure changes associated with rectal distension in anesthetized andawake dogs. This vasoactive reflex serves as a model forvisceral nociception. For intracerebroventricularstudies, the cerebroventricular guides were placed over the lateral ventricle. In anesthetized studies,blood pressure was measured by femoral arterycannulation. In awake studies, blood pressure wasmonitored by noninvasive measurement. A rectal balloonwas placed in the rectum of each dog and maintainedthroughout the experiments. Each dose of alosetron wasgiven to the dogs as an intravenous orintracerebroventricular bolus, and every 30 min therectal balloon was inflated and blood pressure responsesobserved. In both anesthetized and awake dogs alosetronproduced a significant inhibition of the vasoactivereflex. In particular, alosetron showed high potency when administered intracerebroventricularly.Alosetron, administered either centrally orperipherally, appears to modulate the visceralnociceptive effect of rectal distension indogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026633629141
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    Paper (German National Licenses)
    Fulltext
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