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  • Conductivities  (2)
  • acetonitrile  (2)
  • breast cancer  (2)
  • 18-crown-6  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Conductance and ion association in dimethylsulfite (1986)
    Springer
    Journal of solution chemistry 15 (1986), S. 663-673 
    Details
    ISSN: 1572-8927
    Schlagwort(e): Conductivities ; Ion association ; 1∶1 electrolytes ; acetone ; dimethylsulfite
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The electrolytic conductances of LiClO4, LiAsF6, NaClO4 and the n-butylammonium salts Bu4NCl, Bu4NClO4, and Bu4NBPh4 (tetraphenylborate) have been determined in dimethylsufite at 25°C. Ion association constants calculated from these data are interpreted in terms of solvent-separated ion pairs (for LiClO4, LiAsF6, and NaClO4), and contact ion pairs (for the n-butyl-ammonium salts). Comparisons are made for analogous electrolytes in acetone, and in which all salts form contact ion pairs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00644598
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  • 2
    Digitale Medien
    Digitale Medien
    Conductance of 1:1 electrolytes in methyl formate (1987)
    Springer
    Journal of solution chemistry 16 (1987), S. 225-235 
    Details
    ISSN: 1572-8927
    Schlagwort(e): Conductivities ; 1:1 electrolytes ; methyl formate ; ion pairs ; triple ions ; ion solvation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The electrolytic conductivities of LiClO4, LiAlCl4, LiAsF6, NaClO4, NaBPh4, and Bu4NClO4 have been measured in methyl formate at 25°C. Evidence is presented for strong association between the perchlorate ion and the formyl proton of the solvent. Ion association and triple ion formation constants suggest that LiClO4, LiAlCl4, and NaClO4 form solvent separate ion pairs and triple ions. NaBPh4 forms contact ion pairs and triple ions, and the remaining salts appear to form both types of ion pairs and triple ions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00646988
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S11 
    Details
    ISSN: 1573-7217
    Schlagwort(e): autologous hematopoietic cell support ; BCNU ; breast cancer ; carboplatin ; cisplatin ; cyclophosphamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Combinations of alkylating agents in intensive doses with autologous hematopoietic cell support (AHCS) are commonly used to treat advanced, solid tumors. Relatively little is known about the pharmacokinetic or pharmacodynamic aspects of their use. The cyclophosphamide, cisplatin, and BCNU (CPA/cDDP/BCNU) regimen is often used in patients with breast cancer. In these individuals, the blood levels of BCNU vary by more than tenfold. In rats given BCNU, the blood level variability is associated with cisplatin pretreatment, and mean levels are much higher than those that occur when cisplatin pretreatment is omitted. These observations suggest that a major elimination pathway for BCNU is metabolic and is subject to cisplatin disruption. Between 30–50% of patients receiving the CPA/cDDP/BCNU regimen experience a steroid-responsive pulmonary injury that can be fatal if untreated. Blood levels of BCNU are positively correlated with the risk of pulmonary injury in these patients. Others have demonstrated that blood levels of CPA can be inversely correlated with the likelihood of cardiac toxicity and 2-year, relapse-free survival in patients with breast cancer. Emerging data suggest that circulating drug levels, rather than the calculated dose, best explain the variability of outcome in patients treated with combination alkylating agents and AHCS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00668355
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  • 4
    Digitale Medien
    Digitale Medien
    Complexation of alkali metal cations by calix[4]Arene-bis-crown-6 in methanol, acetonitrile and propylene carbonate (1996)
    Springer
    Journal of solution chemistry 25 (1996), S. 955-970 
    Details
    ISSN: 1572-8927
    Schlagwort(e): Electrolytic conductance ; molar conductance ; ion pair formation ; complex formation ; 18-crown-6 ; calix[4]arene-bis-crown-6 ; lithium perchlorate ; sodium perchlorate ; potassium perchlorate ; rubidium perchlorate ; cesium perchlorate ; acetonitrile ; methanol ; propylene carbonate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Résumé The interactions of Li+, Na+, K+, Rb+, and Cs+ with the “double-crown calix,” calix[4]arene-bis-crown-6, have been studied in methanol, acetonitrile, and propylene carbonate at 25°C using precise conductivity measurements. For Li+ and Na+ in solutions containing this calix[4]arene, only 1:1 cation:ligand complexes are formed which permit the determination of the thermodynamic complexation formation constants,K f. The conductivity data strongly suggest that 2:1 cationcalixarene complexes form with K+, Rb+, and Cs+. The existence of 2:1 complexes was experimentally confirmed for the potassium systems by a mass spectroscopic method.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00972592
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  • 5
    Digitale Medien
    Digitale Medien
    Conductivities of 1∶1 salts in 2-cyanopyridine (1994)
    Springer
    Journal of solution chemistry 23 (1994), S. 579-593 
    Details
    ISSN: 1572-8927
    Schlagwort(e): 2-Cyanopyridine ; conductivities ; 1∶1 electrolytes ; dilute solutions ; single ion molar conductivities ; ion association ; mixed solvents ; acetonitrile ; concentrated solutions ; LiAsF6 ; high energy density lithium batteries
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Electrolytic conductivities of eight simple 1∶1 electrolytes have been measured in dilute solutions of 2-cyanopyridine (2CNP) at 30°. Infinite dilution mobilities and association constants were calculated using the Fuoss-Hsia equation. With the exception of LiCF3SO3 all salts show very little association, consistent with the very high dielectric constant of 2CNP. The weak association which does occur is attributed to weak ion-solvent interactions. No evidence was found for triple ion formation. Conductivities of concentrated solutions of LiAsF6 in 2CNP increase slowly with concentration reaching a maximum at a concentration of around 0.65 mol-dm−3. These conductances are slightly lower than those in propylene carbonate which has a lower dielectric constant and a higher viscosity. Conductivities of concentrated LiAsF6 solutions in 2CNP mixtures with acetonitrile vary monotonically, consistent with solution viscosities, and show no sign of the maximum commonly observed in mixed organic solvents.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00972746
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  • 6
    Digitale Medien
    Digitale Medien
    New strategies in marrow purging for breast cancer patients receiving high-dose chemotherapy with autologous bone marrow transplantation (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S19 
    Details
    ISSN: 1573-7217
    Schlagwort(e): amifostine ; autologous bone marrow transplantation (ABMT) ; breast cancer ; 4-hydroperoxycyclophoshamide (4-HC) ; marrow purging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary High-dose chemotherapy and autologous bone marrow transplantation (ABMT) are commonly used to treat selected patients with high-risk breast cancer. A limitation of ABMT is that clonogenic cancer cells could be collected with the bone marrow and produce a relapse of disease when reinfused into patients. Purging the marrowex vivo may eliminate the tumor cells, but it can also delay engraftment. We employed two different purging methods whereby breast cancer cells were depleted without delaying engraftment. The addition of WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) reduced the time to engraftment by 10 days compared with marrow purged with 4-HC alone (26 versus 37 days, respectively). The positive selection of CD34+ hematopoietic progenitors produced engraftment within 21 days. The use of granulocyte colony-stimulating factor (G-CSF) accelerated the engraftment time of CD34+ hematopoietic progenitors to 11 days.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00668356
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