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  • 1
    Electronic Resource
    Electronic Resource
    The proto-oncogene C-raf-1 is highly expressed only in the hypertrophic zone of the growth plate (1994)
    Springer
    Calcified tissue international 54 (1994), S. 426-430 
    Details
    ISSN: 1432-0827
    Keywords: Proto-oncogene ; C-raf-1 ; Growth plate ; Chondrocyte ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Proto-oncogene c-raf-1, the cellular homologue of the acutely transforming oncogene v-raf, has a central role in the signal tranduction pathways. The growth plate, due to its non-overlapping zones of chondrocyte maturation, provides a physiological in situ model for investigating the role of c-raf-1 in proliferation and differentiation of chondrocytes. In this study, Northern blotting was first performed to examine the expression of mRNA for c-raf-1 in the embryonic chick tibial growth plate. It revealed that the normal levels of c-raf-1 mRNA were associated with the whole growth plate. We then investigated the localization of c-raf-1 mRNA and c-raf-1 protein in the growth plate by in situ hybridization and immunohistochemistry in order to determine whether c-raf-1 is involved in chondrocyte maturation. Our results showed that c-raf-1 mRNA and c-raf-1 protein were detected only in the hypertrophic zone. The data suggest involvement of this proto-oncogene in chondrocyte differentiation and/or hypertrophy rather than in proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00305531
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  • 2
    Electronic Resource
    Electronic Resource
    Exciton level densities with spin and parity based on random matrix model (1991)
    Springer
    The European physical journal 339 (1991), S. 129-139 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 23.40.Hc ; 21.10.Ma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Level densities for fixedJ π and the exciton number are evaluated for closed shell nuclei40Ca and208Pb. The single particle spectra and wave functions are generated by Woods-Saxon potentials. The effects of the residual interaction are taken into account statistically by the method of generating function and Grassmann integral. The matrix elements for the residual interaction are assumed to be random variables with Gaussian distributions whose second moments are calculated by using a zero range interaction. The second moments are evaluated for fixedJ π by ignoring the Pauli principle between active nucleons and the spectator. This approximation is shown numerically to be very good. The partial level densities are calculated using the second moments as well as independent particle model spectra. The resulting level densities spread over wider energy ranges, have a smoother energy dependence and are enhanced at low energies compared with the independent particle model densities, although the total level densities do not differ by much.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01282942
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    Paper (German National Licenses)
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