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  • 1
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Db receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: Key words 5-Hydroxytryptamine (5-HT ; serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unambiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibition of cyclic AMP formation. 5-HT and the 5-HT1D receptor agonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effect of 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβ receptor mRNA in HUVEC. They support the involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Dβ receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: 5-Hydroxytryptamine (5-HT, serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unamiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibitiion of cyclic AMP formatin. 5-HT and the 5-HT1D receptor agaonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effct pf 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβreceptor mRNA in HUVEC. They support he involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Light charged particle release in252Cf spontaneous fission: Tripartition versus fragment de-excitation (1992)
    Springer
    The European physical journal 341 (1992), S. 481-488 
    Details
    ISSN: 1434-601X
    Keywords: 25.85.Ca
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Double-differential emission probabilities P (E, θ) in angle θ and energy E of protons, tritons, and α-particles were measured in the case of spontaneous fission of252Cf. A detector system consisting of position-sensitive parallel-plate avalanche counters (PPAC) and ΔE−E-telescopes allowed a coincidence measurement of fission fragments (FF) and light charged particles (LCP) in the whole region from 0 deg. to 180 deg. with respect to the light-fragment direction. Previous results for α-particle emission were confirmed. The background contributions for protons are discussed in detail. For proton emission the background arising from (n, p)-reactions was measured and compared with a corresponding Monte-Carlo simulation of elastic (n, p)-clusions. Unlike for tritons and a-particles the P (E, θ) distribution for protons does not show equatorial peaking in 0 between 80 deg. and 90 deg. and contradicts classical scission point emission. The proton distribution, however, agrees with fragment de-excitation calculations in the framework of the cascade evaporation model (CEM) whereas an analogous calculation forα-particles completely fails. Upper limits for an additional scission component of proton emission are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01301393
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Light charged particle release in fission: Tripartition versus fragment de-excitation (1991)
    Springer
    The European physical journal 338 (1991), S. 115-116 
    Details
    ISSN: 1434-601X
    Keywords: 25.85.Ca
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Emission distributions P(E,θ) in energy E and angle θ of protons (p), tritons (t), and ∝-particles released in spontaneous fission of 252-Cf have been measured. Whereas the experimental data for t and ∝ indicate the expected tripartition as the predominant mode, p emission has been found to be due to fragment de-excitation from highly excited, rapidly moving fragments mainly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279123
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    Paper (German National Licenses)
    Fulltext
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