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  • 1
    ISSN: 1432-0630
    Keywords: 72.20.Jv ; 29.40.Pe ; 85.60.Dw
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The photoelectric response of p-n Si photodiodes under pulsed laser illumination (half width 10 ns) at 532 nm was studied as a function of dose which was varied over 6 orders of magnitude. The photocurrent transients are dominated by a plateau-like feature due to the build up of space charge at the intensities used. Increasing bias voltage increases the height of the plateau and decreases its length. In the low-dose range the length of the transient increases linearly with dose and the collected charge (integrated current) reaches a constant value. At high doses (above 10−5 J/pulse · cm2 or 2.7×1013 quanta/pulse · cm2) considerable charge loss (decrease in quantum yields) is accompanied by a less than proportional increase of the transient lifetime. From model calculations the dose and voltage dependence of the quantum yield of charge collection is shown to be the result of competition between current flow and first and higher order recombination. The model calculations are consistent with experimental results. Rate constants have been obtained by fitting.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
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