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  • 1
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Db receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: Key words 5-Hydroxytryptamine (5-HT ; serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unambiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibition of cyclic AMP formation. 5-HT and the 5-HT1D receptor agonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effect of 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβ receptor mRNA in HUVEC. They support the involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Dβ receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: 5-Hydroxytryptamine (5-HT, serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unamiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibitiion of cyclic AMP formatin. 5-HT and the 5-HT1D receptor agaonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effct pf 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβreceptor mRNA in HUVEC. They support he involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Absolute pionic x-ray intensities in Mg and Fe (1991)
    Springer
    The European physical journal 341 (1991), S. 101-105 
    Details
    ISSN: 1434-601X
    Keywords: 36.10.Gv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Absolute pionic x-ray intensities have been measured for Mg and Fe. The accuracy achieved was 2% of the line intensity for the most prominent transitions. In the Balmer series of Mg and the Paschen series of Fe the crossover transitions were found to be even more attenuated than the transitions between circular states, as deduced, for example, by comparison with muonic atoms; no crossover transitions were observed in the Fe Balmer series. According to cascade calculations based on the experimental intensities more than half of the pions are absorbed in Fe already from levels with principal quantum numbern〉17 by strong interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01281280
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    First direct observation of strong interaction spin-orbit effects in antiprotonic atoms (1988)
    Springer
    The European physical journal 329 (1988), S. 235-241 
    Details
    ISSN: 1434-601X
    Keywords: 36.10.Gv ; 13.75.Cs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The strong ¯p-nucleus spin-orbit interaction was investigated in a measurement of the strong-interaction effects of the 9→8 transition in ¯p 174Yb at the Low-Energy Antiproton Ring (LEAR) at CERN. This measurement was part of an experimental programme where, for the first time, the fine-structure components of the last observable X-ray transition in a ¯p atom, which carries information on the strong ¯p-nucleus interaction, were resolved and studied individually. The observed splitting ΔE exp=2408±26 eV consists of the electromagnetic fine-structure splitting ΔE FS=2350 eV and an additional splitting Δɛ=58±26 eV. In addition, one finds a significant difference in the level widths of Δ=195±59 eV with the larger value⇊=1216±41 eV for the lower fine-structure level. This experiment follows an earlier measurement on ¯p 138Ba, where the transition 8→7 is influenced by the strong interaction. In this case, however, the fine-structure components could not be resolved. The results for174Yb may be attributed to a spin-orbit (LS) term in the complex strong-interaction potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01283780
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Measurement of the 4f strong interaction level width in light antiprotonic atoms (1986)
    Springer
    The European physical journal 325 (1986), S. 261-265 
    Details
    ISSN: 1434-601X
    Keywords: 36.10.Gv ; 13.75.Cs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The yields of the atomic 4→3 transitions in antiprotonic14N,16,17,18O,19F, and23Na were measured at the CERN antiproton facility, LEAR. From these, the widths Γup of the 4f levels were determined to be 136±19meV (14N); 603±22 meV (16O); 731±35 meV (17O); 795±23 meV (18O); 2.79±0.16 eV (19F); and 23.8±7.4 eV (23Na).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294606
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    Paper (German National Licenses)
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