ISSN:
1432-1041
Keywords:
Cyclophosphamide
;
Pharmacokinetics
;
4-Hydroxycyclophosphamide
;
Bone marrow Transplantation
;
Total body irradiation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary High-dose cyclophosphamide is used immediately after total body irradiation (TBI) in conditioning for bone marrow transplantation (BMT). Possible interactions of the two treatment modalities were sought by measuring the blood pharmacokinetics of CP and 4-hydroxy-cyclophosphamide (4-HOCP) in patients undergoing BMT. There was a non-significant trend to a shorter half-life of CP compared to reported values. Exposure to 4-HOCP, the major metabolite of CP, did not appear to be altered by prior TBI of the patient.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315233
Permalink