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  • 1
    Electronic Resource
    Electronic Resource
    Clinical relevance of oxygen radicals in inflammatory bowel disease — Facts and fashion (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 1001-1003 
    Details
    ISSN: 1432-1440
    Keywords: Inflammatory bowel disease ; Oxygen radicals-superoxide ; Hydroxyl ; Myeloperoxidase ; Chemoluminescence ; Animal models ; Aminosalicylates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxygen radicals particularly superoxide and hydroxyl radicals are very reactive species believed to be involved in cell and tissue damage in a variety of diseases including inflammatory bowel disease (IBD). Today there are four major arguments for such a role in IBD: Infiltration of the inflamed intestinal mucosa with myeloperoxidase containing activated neutrophils able to produce superoxide, hydroxyl and hypochlorite, increased chemoluminescence response of peripheral and mucosal phagocytic cells to various stimuli, decreased inflammation following specific scavenger treatment in animal models of colitis and defined radical scavenger and inhibitory properties of drugs, especially aminosalicylates used in the therapy of IBD. In the absence of a specific therapy, radical scavenging and/or inhibition may be an adjunctive modality in IBD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01645146
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 417-422 
    Details
    ISSN: 1573-2568
    Keywords: inflammatory bowel disease ; (Na+ + K+)-ATPase ; 5′-nucleotidase ; mucosal inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In inflammatory bowel disease (IBD), mucosal damage and loss of colonic function are regarded as major consequences of inflammation. Decreased colonic (Na+ + K+)-ATPase activities with diminished reabsorption of sodium and water have been found in active stages of ulcerative colitis. In this study, we report an inverse relationship between colonic (Na+ + K+)-ATPase activity and the degree of mucosal inflammation in 19 patients with IBD of mild to moderate disease activity. Various macroscopic and histologic types of mucosal lesions were differently associated with the (Na+ + K+)-ATPase activities. 5′-nucleotidase activity was not associated with the degree of mucosal inflammation or the kind of macroscopic or histologic lesions. Our findings support the view that, in contrast to 5′-nucleotidase, (Na+ + K+)-ATPase activity may better reflect the severity of mucosal damage and the degree of inflammation in IBD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536025
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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