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  • 40Ar/39Ar laserdating  (1)
  • Acetylcholine-receptor antibodies  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Die Bedeutung der Bestimmung von Antikörpern gegen Acetylcholinreceptoren in der Diagnostik der Myasthenia gravis (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 937-942 
    Details
    ISSN: 1432-1440
    Keywords: Myasthenia gravis ; Acetylcholine-receptor ; Acetylcholine-receptor antibodies ; Autoimmune disease ; Plasmapheresis ; Myasthenia gravis ; Acetylcholin-Receptor ; Acetylcholin-Receptor-Antikörper ; Autoimmunerkrankung ; Plasmapherese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 65 Patienten mit Myasthenia gravis (MG) wurden Antikörper gegen Acetylcholin-Receptoren (ACh-R) in der IgG-Fraktion des Patienten-Serums bestimmt (Immunpräzipitations-Assay mit125Jod-α-Bungarotoxin und menschlichem ACh-R als Antigen). Bei 91% der Patienten zeigte sich eine erhöhte Antikörper-Konzentration bis zum 500fachen des oberen Referenzbereichs. Eine Kontrollgruppe von 77 Patienten mit anderen gesicherten Autoimmunerkrankungen oder positiven Antikörpern gegen Muskulatur wies in keinem Fall erhöhte ACh-R-Antikörper-Konzentrationen auf. Damit ist der in-vitro Nachweis von ACh-R-Antikörpern ein empfindlicher und hochspezifischer Test für die Diagnostik der MG. Der Test eignet sich ebenfalls für die Verlaufskontrolle unter Therapie mit Immunsuppressiva oder Plasmapherese. Immunfluoreszenz-Untersuchung auf Antikörper gegen Muskelgewebe ist für die MG-Diagnostik weniger empfindlich und nicht spezifisch.
    Notes: Summary The sera of 65 patients with myasthenia gravis (MG) were analysed for antibodies against the nicotinic acetylcholine receptor (ACh-R) using an immunoprecipitation assay (125I-α-bungarotoxin bound to human ACh-R as antigen). In 91% of MG sera elevated antibody titers were found ranging up to 500 times reference values. A control group of 77 patients showing various autoimmunological phenomena had ACh-R antibody concentrations within the reference range. The demonstration of antibodies against ACh-R provides a sensitive and highly specific tool for the diagnosis of MG. In addition, the test is helpful in following patients under treatment with immunosuppressive drugs or plasmapheresis. Antibodies against striated, smooth, or heart muscle (indirect immunofluorescence test) are much less sensitive and nonspecific for the diagnosis of MG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478550
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  • 2
    Electronic Resource
    Electronic Resource
    Age, geodynamic setting, and mantle enrichment processes of a K-rich intrusion from the Meissen massif (northern Bohemian massif) and implications for related occurrences from the mid-European Hercynian (1997)
    Springer
    Geologische Rundschau 86 (1997), S. 556-570 
    Details
    ISSN: 0016-7835
    Keywords: Key words K-rich rock ; Amphibole ; 40Ar/39Ar laserdating ; Mantle enrichment ; Moldanubian ; Post-collisional intrusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  The plutonic complex of the Meissen massif (northern margin of the Bohemian massif) comprises dioritic to mainly monzonitic and granitic rocks. The diorite to monzonite intrusions show major and trace element patterns typical for shoshonitic series. The chemical signatures of less crustally contaminated diorites are similar to arc-related shoshonitic rocks derived from continental lithospheric mantle (CLM) sources previously enriched by subduction of altered oceanic crust. Laser step heating 40Ar/39Ar analyses on actinolitic to edenitic amphiboles from geographically different occurrences of the monzonitic intrusion yielded concordant plateau ages as well as total gas ages ranging from 329.1±1.4 to 330.4±1.4 Ma and from 330.4±2.1 to 330.6±1.8 Ma, respectively. These cooling ages are indistinguishable from sensitive highresolution ion microprobe (SHRIMP) 238U/206Pb intrusion ages measured on magmatic zircon rims from the monzonite (Nasdala et al., submitted). This shows that the monzonite intrusion is probably not related temporally to active subduction because it postdates eclogites of the adjacent Saxonian Erzgebirge by approximately 20 Ma. The shoshonitic magmas intruded during strike-slip tectonism along the Elbe valley zone. The enrichment of their mantle sources may be of Upper Devonian/Lower Carboniferous age or older. Intrusions of shoshonitic to ultra-potassic (K-rich) rocks during the Upper Visean/Namurian are widespread in the Moldanubian zone. Based on similar ages and structural relationships a similar post-collisional setting to the Meissen shoshonitic rocks can be demonstrated. Most of these occurrences cut high-grade nappe units which were subducted during the Upper Devonian/Lower Carboniferous. In contrast to the Meissen massif, at least the ultra-potassic members of the Central and the South Bohemian batholiths were derived from CLM sources enriched by fluids or melts released from subducted oceanic crust and by greater portions of crustal material. Despite the similar post-collisional geodynamic setting of the K-rich intrusions, different enrichment processes generated mid-European Hercynian CLM sources with heterogeneous major and trace element and isotopic signatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005310050163
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    Paper (German National Licenses)
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