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  • 1
    Electronic Resource
    Electronic Resource
    Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 152-154 
    Details
    ISSN: 1432-069X
    Keywords: Arotinoids ; Sebum production ; Acne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]-naphtalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1,2,3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456845
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 481-485 
    Details
    ISSN: 1432-069X
    Keywords: Cyproterone acetate ; Ethinyl estradiol ; Sebum secretion ; Sebum composition ; Linoleic acid ; Acne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of high-dose cyproterone acetateethinyl estradiol treatment on rates of sebum secretion and on the proportions of linoleic acid (18∶2Δ9,12) and sebaleic acid (18∶2Δ5,8) in the skin surface lipids of three female acne patients was examined. Changes in rates of sebum secretion were evaluated indirectly by measuring the ratio of wax esters/(cholesterol +cholesterol esters) in the subjects' skin surface lipid. In two of the subjects, this ratio indicated a reduction of sebum secretion rates to the childhood range. Concomitantly, there was an increase in linoleic acid and a decrease in sebaleic acid in all lipid classes. In the third subject, in whom there was only a small reduction in sebum secretion rate, the proportion of linoleic acid in the cholesterol esters more than doubled, but the changes in the other lipid classes were small or nonexistent. The results indicate that the proportions of linoleic acid and sebaleic acid in sebum are influenced by sebum secretion rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455168
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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