Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Apolipoprotein E type 4 allele and Alzheimer's disease: Effect on age at onset and relative risk in different age groups (1996)
    Springer
    Journal of neurology 243 (1996), S. 452-456 
    Details
    ISSN: 1432-1459
    Keywords: Alzheimer's disease ; Apolipoprotein E ; Age at onset ; Relative risk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of the apolipoprotein E (apoE) genotype on the age at onset of Alzheimer's disease (AD) and the relative risk conferred by the apoE ε4 allele were studied in 91 patients and 69 healthy age-matched controls. According to the age of presentation, which varied from 44 to 95 years, subjects were divided into four groups. The inheritance of at least one ɛ4 allele was associated with a significant reduction of the age at onset by 7.7 years among patients who were 83 years or older when examined. A weaker inverse relationship between the ɛ4 allele and the age at onset was also observed among patients who were aged 44–63 years at presentation. The effect of the c4 allele was minimal or absent in the two intermediate age categories. The relative risk of AD conferred by the inheritance of at least one £4 allele showed no consistent age-related pattern. The overall risk expressed as an odds ratio was 5.0 (95% CI 2.4–10.5). With respect to the limitations of the study, we tentatively conclude (1) that the effect of the apoE ɛ4 allele on the age at onset is not restricted to AD patients of a particular age, in accordance with current hypotheses on the role of apoE gene products in the biology of AD; (2) that the relative risk of AD associated with the ɛ4 allele is not significantly modulated by age. Although the apoE ɛ4 allele is an important susceptibility factor for AD occurring in middle age as well as in later life, it is of limited value in routine clinical diagnosis and should not be used for predictive testing in asymptomatic individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00900498
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Bildung, Kristallstruktur und absolute Konfiguration von (-)-N-(Chloromethyl)galanthaminium-chlorid (1994)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 77 (1994), S. 1611-1615 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Formation, X-Ray Crystal Structure, and Absolute Configuration of (-)-N-(Chloromethyl)galanthaminium ChlorideThe acetylcholinesterase inhibitor galanthamine (1), main alkaloid of several Narcissus species, readily forms a quaternary ammonium salt by reaction with the solvent CH2Cl2. The structure and absolute configuration of (-)-N-(chloromethyl)galanthaminium chloride (2) were determined by X-ray diffraction (R = 0.075 for 2775 observed independent reflexions) and NMR spectroscopy. The tetragonal crystals (space group P43) contain two crystallographically independent cations which do not differ significantly from one another. The CH2Cl group is attached to the quaternary N-atom in stereospecific (R)-configuration. In the crystal, the configurational position of the Me group at the N-atom of 2 differs from that of the crystalline free base 1. Hydrogen bonding is observed from the OH group at C(3) of 2 to the Cl- anion or to the Cl-atom of an adjacent cation.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19940770617
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Intramolekulare Addition von Carbanionen an Anthrachinone (1984)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1984 (1984), S. 306-318 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Intramoleclar Addition of Carbanions to AnthraquinonesThe intramolecular Michael addition of the carbanions derived from the β-keto diesters 15a and 15b yields the naphthacenequinones 20a and 20b. In contrast, the similar dimethyl ether 11 cyclizes to give the benzo[α]anthracenequinone 17. The hydroquinone of 1,8-dihydroxyanthraquinone (5a) reacts with acrylate to yield the unusual anthrone derivatives 12b and 12c.
    Notes: Die intramolekulare Michael-Addition der Carbanionen, die sich von den β-Ketodiestern 15a und 15b ableiten, liefert die Naphthacenchinone 20a und 20b. Dagegen cyclisiert der Dimethylether 11 zum Benzo[α]anthracenchinon 17. Das Hydrochinon des 1,8-Dihydroxyanthrachinons (5a) reagiert mit Acrylsäureester zu den ungewöhnlichen Anthron-Derivaten 12b und 12c.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198419840213
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    über die Bildung einer Rubazonsäure aus Phenylhydrazinderivaten der Zucker (1961)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 648 (1961), S. 96-113 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Einwirkung von Perjodat auf Dextran, Xylan, Inulin und Saccharose führt zu Oxydationsprodukten dieser Zucker, die mit Phenylhydrazin unter anderem Abkömmlinge der Rubazonsäure ergeben.  -  Die gleichen Verbindungen entstehen bei Einwirkung von asymmetrisch disubstituierten Arylhydrazinen auf D-Fructoson-1-phenylhydrazon oder auf Glycerose-phenylosazon und durch Umsetzung von Glycerinaldehyd-methylphenylhydrazon mit Phenylhydrazin. Es wird über Synthese und Eigenschaften dieser Verbindungen berichtet.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.19616480114
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...