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  • 2005-2009
  • 2000-2004  (1)
  • 1995-1999  (1)
  • 1960-1964
  • Aging effects  (1)
  • Anosmia  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Age-related changes in the compound action potentials of the eighth nerve in guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 145-149 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Eighth nerve compound action potential ; Aging effects ; Guinea pig
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The eighth nerve compound action potential (CAP) in 95 guinea pigs was measured using click stimuli to investigate age-related changes in their neural auditory thresholds. The animals were separated into three groups: group A (n = 43, 86 ears; 2–4 months old); group B (n = 29; 58 ears, 13–15 months old); and group C (n = 23; 46 ears, 23–25 months old). With increasing age, a gradual elevation of CAP thresholds was clearly seen among the three groups. The negative peak (N1) latencies of the CAP were prolonged, and the N1 amplitudes of the CAP decreased. There were significant differences in N1 latencies among the three groups and in N1 amplitudes between groups A and B, and between groups A and C. However, the rate of decline of the thresholds as well as the input-output function curves of the CAP varied in some of the oldest animals, suggesting that there were some individual differences in degenerative aging processes of the auditory system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471279
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A novel interstitial deletion of KAL1 in a Japanese family with Kallmann syndrome (2000)
    Springer
    Journal of human genetics 45 (2000), S. 237-240 
    Details
    ISSN: 1435-232X
    Schlagwort(e): Key words Kallmann syndrome ; KAL1 ; Mutation ; Anosmia ; Hypogonadism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract We identified a novel interstitial deletion that spanned from exons 5 to 10 of KAL1 in two Japanese brothers with X-linked Kallmann syndrome (KS; MIM no. 308700). Both brothers had hypogonadism, unilateral renal agenesis, and disturbance of the sense of smell, but they had no other neurological manifestations, including mental disturbance. Their mother was confirmed to be an asymptomatic carrier, by use of a comparative multiplex polymerase chain reaction (PCR) analysis. The present patients are further examples of patients with KS without mental disturbance caused by a mutation confined to KAL1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100380070033
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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