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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Diabetologia 37 (1994), S. 781-787 
    ISSN: 1432-0428
    Schlagwort(e): Intestinal lipoproteins ; Sf〉400 fraction ; Sf 20–400 fraction ; insulin resistance ; insulin suppression test ; steady-state plasma glucose ; steady-state plasma insulin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate content in plasma and the Svedberg flotation index (Sf)〉400 and Sf 20–400 lipoprotein fractions. Fasting plasma glucose concentrations (14.5±0.5 vs 9.0±0.5 mmol/l), glycated haemoglobin levels (13.1±0.6 vs 9.7±0.6%), and daylong plasma glucose concentrations were all significantly lower after glipizide treatment (p〈0.001). The improvement in glycaemic control was associated with increases in insulin-mediated glucose uptake (p〈0.001) and plasma post-heparin lipoprotein and hepatic lipolytic activities (p〈0.02). Both fasting plasma triglyceride (3.09±0.51 vs 2.37±0.34 mmol/l), and postprandial triglyceride concentrations (p〈0.05–0.001) were lower following glipizide treatment, associated with a significant fall in retinyl palmitate content in all three lipoprotein fractions (p〈0.02–0.001), with the most substantial decrease seen in the Sf 20–400 fraction. These data indicate that glipizide-induced improvement in glycaemic control was associated with changes in the metabolism of triglyceride-rich lipoproteins of intestinal origin that would be anticipated to reduce risk of coronary heart disease in non-insulin-dependent diabetic patients.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    International journal of fracture 101 (2000), S. 161-180 
    ISSN: 1573-2673
    Schlagwort(e): Micromechanical modeling ; cohesive force ; fracture ; heterogeneous materials ; elasticity ; fracture modes ; failure modes ; numerical simulation ; crack propagation ; ceramic composites.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract A micromechanical model that provides explicit accounts for arbitrary microstructures and arbitrary fracture patterns is developed and used. The approach uses both a constitutive law for the bulk solid constituents and a constitutive law for fracture surfaces. The model is based on a cohesive surface formulation of Xu and Needleman and represents a phenomenological characterization for atomic forces on potential crack/microcrack surfaces. This framework of analysis does not require the use of continuum fracture criteria which assume, for example, the existence of K-fields. Numerical analyses carried out concern failure in the forms of crack propagation and microcrack formation. Actual microstructures of brittle alumina/titanium diboride (Al2O3/TiB2) composites are used. The results demonstrate the effects of microstructure and material inhomogeneities on the selection of failure modes in this material system. For example, the strength of interfaces between the phases is found to significantly influence the failure characteristics. When weak interfacial strength exists, interfacial debonding and microcrack initiation and growth are the principal mode of failure. When strong interfacial strength is derived from material processing, advancement of a dominant crack and crack branching are observed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 48 (1998), S. 671-676 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Paralytic shellfish poisoning (PSP) ; Alexandrium tamarense
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Improvements to an established HPLC method are introduced. The modified method is more efficient for separation and detection of the toxins reponsible for paralytic shellfish poisoning (PSP). The PSP toxin cotent of two strains ofAlexandrium tamarense and approximately forty shellfish samples collected from different locations in China have been analyzed with this HPLC method. Only one shellfish sample, collected from Lianyungang, China, contained PSP toxins.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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