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  • 1
    Electronic Resource
    Electronic Resource
    Effect of glipizide treatment on postprandial lipaemia in patients with NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 781-787 
    Details
    ISSN: 1432-0428
    Keywords: Key words Intestinal lipoproteins, Sf 〉400 fraction, Sf 20–400 fraction, insulin resistance, insulin suppression test, steady-state plasma glucose, steady-state plasma insulin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate content in plasma and the Svedberg flotation index (Sf) 〉400 and Sf 20–400 lipoprotein fractions. Fasting plasma glucose concentrations (14.5±0.5 vs 9.0±0.5 mmol/l), glycated haemoglobin levels (13.1± 0.6 vs 9.7±0.6 %), and daylong plasma glucose concentrations were all significantly lower after glipizide treatment (p〈0.001). The improvement in glycaemic control was associated with increases in insulin-mediated glucose uptake (p〈0.001) and plasma post-heparin lipoprotein and hepatic lipolytic activities (p〈0.02). Both fasting plasma triglyceride (3.09±0.51 vs 2.37± 0.34 mmol/l), and postprandial triglyceride concentrations (p〈0.05–0.001) were lower following glipizide treatment, associated with a significant fall in retinyl palmitate content in all three lipoprotein fractions (p〈0.02–0.001), with the most substantial decrease seen in the Sf 20–400 fraction. These data indicate that glipizide-induced improvement in glycaemic control was associated with changes in the metabolism of triglyceride-rich lipoproteins of intestinal origin that would be anticipated to reduce risk of coronary heart disease in non-insulin-dependent diabetic patients. [Diabetologia (1994) 37: 783–787]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404335
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of glipizide treatment on postprandial lipaemia in patients with NIDDM (1994)
    Springer
    Diabetologia 37 (1994), S. 781-787 
    Details
    ISSN: 1432-0428
    Keywords: Intestinal lipoproteins ; Sf〉400 fraction ; Sf 20–400 fraction ; insulin resistance ; insulin suppression test ; steady-state plasma glucose ; steady-state plasma insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate content in plasma and the Svedberg flotation index (Sf)〉400 and Sf 20–400 lipoprotein fractions. Fasting plasma glucose concentrations (14.5±0.5 vs 9.0±0.5 mmol/l), glycated haemoglobin levels (13.1±0.6 vs 9.7±0.6%), and daylong plasma glucose concentrations were all significantly lower after glipizide treatment (p〈0.001). The improvement in glycaemic control was associated with increases in insulin-mediated glucose uptake (p〈0.001) and plasma post-heparin lipoprotein and hepatic lipolytic activities (p〈0.02). Both fasting plasma triglyceride (3.09±0.51 vs 2.37±0.34 mmol/l), and postprandial triglyceride concentrations (p〈0.05–0.001) were lower following glipizide treatment, associated with a significant fall in retinyl palmitate content in all three lipoprotein fractions (p〈0.02–0.001), with the most substantial decrease seen in the Sf 20–400 fraction. These data indicate that glipizide-induced improvement in glycaemic control was associated with changes in the metabolism of triglyceride-rich lipoproteins of intestinal origin that would be anticipated to reduce risk of coronary heart disease in non-insulin-dependent diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404335
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Surface chemical properties of biopolymers determined by contact angle measurements (1978)
    Springer
    Colloid & polymer science 256 (1978), S. 261-265 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary The surface chemical properties of various biopolymer solids, e.g. fibrinogen, BSA, Lysozyme and denatured BSA, were studied by measuring the contact angles of the liquid-solid interface. The magnitude of the solid surface tension, γ S D , determined from Fowkes' relations for the various biopolymers was found to be ≈ 37.0 dyne/cm. These results show that the dispersion force component of γs is of the same order of magnitude for proteins with different polarapolar character. The films of denatured BSA also show that the dispersion force component ofys does not change on denaturation, even though the polarapolar character of the protein changes on denaturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550556
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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