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  • 1
    ISSN: 0167-0115
    Keywords: Angiotensin ; Arginine vasopressin ; Human ; Hymenoptera venom anaphylaxis ; Oxytocin ; Plasma concentration
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 279 (1987), S. 536-542 
    ISSN: 1432-069X
    Keywords: Histamine ; IgE ; Prostaglandin E2 ; Basophils ; Atopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of arachidonic acid (AA) metabolism upon histamine release (HR) from human basophils after stimulation with anti-IgE was studied in 23 atopic and 11 normal individuals. HR occurred significantly faster in atopics than in normals; the total amount of HR after a 40 min incubation period was not significantly different between the two groups. Indomethacin and acetylsalicylic acid (ASA) increased the quantity of HR significantly both in atopics and normals without influencing the time course. Addition of exogenous PGE2 decreased HR; here atopics were more affected than normals 5 and 10 min after challenge with anti-IgE. Production of PGE2 after stimulation with anti-IgE was very low in both groups (in the range of 30–50 pg/106 cells) and often below detection limit (10–20 pg/ml). Addition of glutathione (GSH), a coenzyme of PGE2-isomerase, increased PGE2 production 2 to 5-fold during stimulation with anti-IgE. These data support the idea that arachidonic acid metabolites play an important role in modulating the “releasability” of human basophils. It is suggested that the basophils of atopic individuals may release their histamine faster than normals — perhaps on the basis of a more slowly acting endogenous feedback mechanism by PGE2. Both phenomena support the idea of an altered “releasability” of basophils from atopics compared to normals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Reproduktionsmedizin 16 (2000), S. 183-188 
    ISSN: 1434-808X
    Keywords: Keywords IgE antibodies • Seminal plasma • Allergy • Ejaculate • Anaphylaxis ; Schlüsselwörter IgE-Antikörper ; Sperma ; Seminalplasma ; Allergie ; Anaphylaxie ; Ejakulat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Echte Spermaallergien sind von allergischen Reaktionen gegen Latex, spermizide Substanzen, Lokalanästhetika oder Bestandteile von Lubrikantien abzugrenzen. Inhalt dieses Übersichtsartikels sind IgE-vermittelte allergische Reaktionen (Typ I) auf spezifische Bestandteile des Seminalplasmas. Derartige Zwischenfälle sind selten, wenn auch von einer erheblichen Dunkelziffer ausgegangen werden muss. Die meisten betroffenen Frauen sind jünger als 40 Jahre und weisen eine atopische Eigen- und Familienanamnese auf. Sensibilisierungen gegen Bestandteile des Seminalplasmas sind nicht immer mit Infertilität assoziiert. Die Beschwerden treten unmittelbar oder innerhalb einer Stunde nach Kontakt mit Sperma auf. Lokale Reaktionen sind Juckreiz, Brennen, Erytheme und Ödeme im Vulvabereich oder an anderen Kontaktstellen des Spermas. Systemische Reaktionen äußern sich als Dyspnoe, Schluckstörungen, rhinokonjunktivale Beschwerden, generalisierte Urtikaria, Angioödeme, gastrointestinale Symptome, Exazerbation eines vorbestehenden atopischen Ekzems oder anaphylaktischer Schock. Symptome können bereits während des ersten Geschlechtsverkehrs auftreten. Einige Ergebnisse sprechen dafür, dass die Allergene aus der Prostata stammen und das prostataspezifische Antigen klinisch relevant ist. Die Diagnostik von Spermaallergien basiert auf Anamnese, Nachweis spezifischer IgE-Antikörper im Serum und evtl. Hauttestungen. Therapeutische Optionen sind Allergenkarenz durch Verwendung von Kondomen sowie Versuch einer Hyposensibilisierung.
    Notes: Abstract Human seminal plasma anaphylaxis has to be differentiated from allergic reactions to latex, spermicidal substances, local anesthetics or components of lubricants. In this review article, IgE-mediated (type I) allergic reactions against seminal plasma antigens are discussed. Corresponding symptoms have rarely been reported. However, it is likely that a significant number of cases remain unpublished or undiagnosed. Most patients are younger than 40 years. Human seminal plasma anaphylaxis is not always associated with female infertility. Symptoms start immediately or within 1 h after exposure to the ejaculate. Local reactions include itching, burning, erythema and edema of the perivaginal region or other areas that have been exposed to seminal plasma. Systemic reactions are dyspnea, dysphagia, rhinitis, conjunctivitis, urticaria, angioedema, gastrointestinal symptoms, anaphylaxic shock or exacerbation of atopic eczema. These complaints may become manifest during the first sexual intercourse. Available data imply that seminal plasma allergens are of prostatic origin and that prostate specific antigen is one of the clinically relevant components. The diagnostic procedure is based on medical history, evaluation of specific IgE antibodies in the serum of patients and skin tests. Patients are advised to avoid allergen contact by proper use of condoms. In occasional cases specific hyposensitization has been performed successfully.
    Type of Medium: Electronic Resource
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