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  • 1
    Digitale Medien
    Digitale Medien
    Safety and efficacy of interferon retreatment in children with chronic hepatitis B (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 382-385 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Key words Chronic hepatitis B ; Children ; Alpha-interferon ; Non-responder ; Retreatment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract More than 50% of children with chronic hepatitis B do not respond to treatment with alpha-interferon. Since these patients continue to display high viral replication and progressive liver disease, retreatment should be considered. To date it has not been well evaluated whether a second course of treatment could increase the response rate. In two alpha-interferon retreatment trials in adult patients the response rate, defined by seroconversion from HBeAg to anti-HBe, ranged between 11% and 44%. One beta-interferon retreatment study in children reported a seroconversion rate of 32%. Regrettably, none of the studies included a control group observing the `spontaneous' seroconversion rate after a first interferon cycle. Thus, a nonrandomized alpha-interferon retreatment study in children including control patients was performed. Alpha-interferon for retreatment was administered 3 times a week for 16–24 weeks in 15 children (5–16 years) at least 6 months after ceasing the first cycle. Four children received 5 MU/m2 of a natural alpha-interferon and 11 children 9 MU/m2 recombinant alpha-interferon 2b. Follow up was 18–47 months after initial treatment. In parallel, a control group of 19 un-retreated children with comparable clinical and demographic data was followed for 12–39 months. HBeAg seroconversion was observed in 5 (33%) of the retreated children and in 5 (26%) of the control patients during follow up. The difference is not significant. In the initially nonresponding children, those with high ALT levels before the first treatment showed late HBeAg seroconversion more frequently than those with low ALT levels (P = 0.017) irrespective of retreatment. The ALT level before retreatment was not a predictor for response. Conclusions A second cycle of alpha-interferon during the 3 years following the first treatment in nonresponding children with chronic hepatitis B can be safely performed but did not increase HBeAg/anti-HBe seroconversion compared with the spontaneous seroconversion rate of patients without retreatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004310050834
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of pair fluctuations on the electronic properties of the negative Hubbard model (1995)
    Springer
    Journal of low temperature physics 99 (1995), S. 315-317 
    Details
    ISSN: 1573-7357
    Schlagwort(e): 74.20Mn ; 74.25.−q ; 74.72.−h
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Based on the fact that high-Tc superconductors exhibit strong fluctuations, we have allowed the presence of pair fluctuations in the framework of the T-matrix formalism using the 2-D negative Hubbard model for temperatures above and below Tc. Our equations are fully self-consistent. For T ≥ Tc the electronic properties change drastically with respect to BCS treatment, namely, there is a pseudogap around the chemical potential in the density of states, and the spectral function, A(k,ω), vs. ω exhibits a double peak structure which is related to the appearance of this pseudogap. For T ≤ Tc, we have generalized the formalism in order to include the order parameter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00752300
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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