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  • 1
    Electronic Resource
    Electronic Resource
    Effects of early insulin treatment on ultrastructural changes of glomeruli in diabetic rats revealed by the quick-freezing and deep-etching method (1996)
    Springer
    Diabetologia 39 (1996), S. 632-640 
    Details
    ISSN: 1432-0428
    Keywords: Quick-freezing ; deep-etching ; glomerulus ; insulin treatment ; streptozotocin-diabetic rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The three-dimensional ultrastructure of glomerular basement membrane (GBM) and mesangial matrix (MM) at an early stage of streptozotocin (STZ)-induced diabetes mellitus in rats was examined by the quick-freezing and deep-etching method. In diabetic rats, the GBM inner layer was diffusely enlarged and the meshwork structure not only in the GBM middle layer but also in the MM became markedly irregular due to the rupture of fine fibrils. This irregularity and enlargement of the mesh pores in diabetic rats developed during the experimental period and was significantly different from results in control rats. Insulin treatment from 1 week after STZ injection had significant effects in preventing the ultrastructural changes in the GBM and MM. It is suggested that early insulin treatment has significant effects in preventing size barrier disturbance of GBM and MM in STZ-induced diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418534
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effects of early insulin treatment on ultrastructural changes of glomeruli in diabetic rats revealed by the quick-freezing and deep-etching method (1996)
    Springer
    Diabetologia 39 (1996), S. 632-640 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Quick-freezing ; deep-etching ; glomerulus ; insulin treatment ; streptozotocin-diabetic rats.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The three-dimensional ultrastructure of glomerular basement membrane (GBM) and mesangial matrix (MM) at an early stage of streptozotocin(STZ)-induced diabetes mellitus in rats was examined by the quick-freezing and deep-etching method. In diabetic rats, the GBM inner layer was diffusely enlarged and the meshwork structure not only in the GBM middle layer but also in the MM became markedly irregular due to the rupture of fine fibrils. This irregularity and enlargement of the mesh pores in diabetic rats developed during the experimental period and was significantly different from results in control rats. Insulin treatment from 1 week after STZ injection had significant effects in preventing the ultrastructural changes in the GBM and MM. It is suggested that early insulin treatment has significant effects in preventing size barrier disturbance of GBM and MM in STZ-induced diabetes. [Diabetologia (1996) 39: 632–640]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418534
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ambiguous motoneurons discharging synchronously with ultrasonic vocalization in rats (1983)
    Springer
    Experimental brain research 50 (1983), S. 359-366 
    Details
    ISSN: 1432-1106
    Keywords: Ambiguous motoneurons ; Ultrasonic vocalization ; Unitary discharges ; Respiration ; Ventral division
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unit discharges associated with ultrasonic vocalization were recorded from the rat medullary region including the nucleus ambiguous (NA). Three types of units were distinguished: ultrasound-related (US), expiration (EXP) and inspiration (INSP) units. Both US and EXP units discharged with tonic bursts mostly prior to ultrasounds. US units were silent during respiration while EXP units discharged synchronously with expiration. During ultrasonic vocalization INSP units suppressed their discharges which were otherwise synchronized with inspiration. Histological examination revealed that US and EXP units were recorded from the ventral division of the NA and the adjacent medullary region where the NA contained large cells and the adjacent region consisted of small cells. These results suggest that both US and EXP units are NA motoneurons responsible for ultrasound emission. EXP units were always supplied with respiratory afferents while US units were not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239201
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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