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Digitale Medien

Effects of cyclosporin on serum hyaluronan levels in collagen arthritis (1995)

Takagishi, K. ; Itoman, M. ; Goso, Y. ; [weitere]

Springer

Inflammation research 44 (1995), S. 79-82

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Details

ISSN: 1420-908X

Schlagwort(e): Collagen ; Arthritis ; Cyclosporin and hyaluronan

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01793217

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