ISSN:
1432-0533
Keywords:
Rat brain tumors
;
Granular cell tumors
;
Immunohistochemistry
;
Astrocytoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have studied paraffin-embedded specimens of 17 rat granular cell brain tumors (GCBT) from four long-term drug safety carcinogenicity studies by peroxidase-antiperoxidase (PAP) immunohistochemistry with either polyvalent or monoclonal antibodies against glial fibrillary acidic protein (GFAP), S-100 protein (S-100), Leu-7 epitopes, vimentin (VIM), keratin, desmin, and myelin basic protein. We have found that 9 of the 17 GCBT contained GFAP-positive, S-100-positive, and VIM-positive astrocytes, while GFAP-positive and VIM-positive granular cells were observed in 5 of these 9 tumors. Our findings indicate that astroglial cells are involved in rat GCBT and suggest that an astrocytic origin should be considered for these neoplasms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00293953
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