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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 157-159 
    ISSN: 1432-1335
    Keywords: Experimental colorectal carcinoma ; Autochthonous tumor model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-methylamine (AMMN) which are used worldwide for etiological and therapy studies of colon cancer are compared for tumor biology and clinical relevance. The four tumor models of colon carcinoma described in the rat are different in growth, invasion, and metastases. The choice of the selected tumor model for experimental investigations of colon cancer should depend on the clinical question.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 764-765 
    ISSN: 1435-2451
    Keywords: Long-term results ; Total gastrectomy ; Gastrektomie ; Langzeitergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1676 Patienten, bei denen nach verschiedenen OP-Verfahren der Magenersatz nach totaler Gastrektomie durchgeführt wurde, wurden auf folgende Parameter untersucht: Reflux, Dumping-Syndrom, Diarrhoe, Gewichtsverlust über 5 kg. Unabhängig von der OP-Art waren Letalität (10–12 %) und Insuffizienzrate (8–12 %) vergleichbar. Folgerungen: 1. Unter den 7 verglichenen OP-Verfahren scheint die Roux-Anastomose unter Berücksichtigung des Risikos eines Refluxes (18%) und des Dumping-Syndroms (18 %) am günstigsten. 2. Die Jejunuminterposition (70 cm Länge) ergibt die besten funktionellen Ergebnisse. 3. Die Wiederherstellung der Reservoirfunktion des Magens ist durch jedes der beschriebenen Verfahren möglich.
    Notes: Summary A total of 1676 patients who had total gastrectomies by different surgical procedures were checked up for the following parameters: reflux, dumping syndrome, diarrhoea, weight loss over 5 kg. We compared the results of seven different procedures. Independent of the surgical technique, operative mortality (10 %–12 %) and rate of leakage (8 %–12 Y.) were comparable. Conclusions: (1) The Roux procedure seems to be the most advantageous as regards reflux (18 %) and dumping syndrome (18 %). (2) Jejunum interposition gives the best functional results. (3) Reconstruction of the reservoir function is possible with the seven procedures described.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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