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  • 1985-1989  (2)
  • Avian embryos  (1)
  • Central nervous toxicity  (1)
  • 1
    ISSN: 1432-1076
    Schlagwort(e): Nephrotic syndrome ; Chlorambucil ; Central nervous toxicity ; Diffuse spike and wave complex
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Chlorambucil (CHL) was used in combination with prednisolone in the treatment of nine children with frequently relapsing nephrotic syndrome. Serial electroencephalograms were obtained to evaluated CHL central nervous toxicity, before, during and after treatment with this agent. EEG abnormalities were observed in two of the nine children during chlorambucil therapy. EEG changes were diffuse spike and wave complexes and disappeared after discontinuation of therapy. There were no other neurological abnormalities and more particularly, no seizures or myocloni were observed. According to the literature, chlorambucil central nervous toxicity is found almost exclusively in childhood nephrotic syndrome. Strict neurological supervision of patients treated with chlorambucil is recomended.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Medical & biological engineering & computing 27 (1989), S. 399-404 
    ISSN: 1741-0444
    Schlagwort(e): Avian embryos ; Ballistocardiogram ; Heart rate monitoring ; Noninvasive measurement ; Signal processing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract A noninvasive heart rate (HR) monitoring system for avian embryos has been developed based on the ballistocardiogram (BCG). The BCG was detected using a phonograph cartridge as a record of the velocity of the minute ballistic movements of the eggshell, which are generated by recoil and impact of heart contraction and blood ejection. The autocorrelation coefficients (ACCs) of the detected signal were computed to confirm whether the detected signal contained ballistic movement. An envelope of ACC was calculated by the monitoring system to measure the intervals between peaks and/or highly correlated parts in the ACC, and then the system obtained HR by measuring these intervals. To demonstrate the valid range of the detecting method, the BCGs of chickens and Japanese quail embryos of different ages were measured. The result of the experiment shows that the BCGs of chickens and quail embryos are detected fully after about two-thirds of the incubation period has passed. The monitoring system will enable us to perform long-term HR measurement for developing avian embryos up to hatching.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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