ISSN:
1432-0584
Keywords:
Side effects of cytotoxic therapy
;
BCNU
;
Acute leukaemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In two patients with acute leukaemia, the development of progressive interstitial pulmonary fibrosis was observed following chemotherapy with BCNU, Cytoxan and Ara-C. The x-ray changes were accompanied by restrictive changes of pulmonary function and, later on, by severe hypoxia. Serologic tests did not reveal infection with cytomegaly virus or mycoplasma pneumoniae. These findings, together with reports in the literature, suggest a toxic effect of BCNU on the lung. The combination with Cyclophosphamide may contribute to this toxic reaction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01000593
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