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  • Bone marrow biopsy  (1)
  • Key words Myelodysplastic syndromes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Plasma cell leukemia with myelofibrosis (1994)
    Springer
    Annals of hematology 69 (1994), S. 151-152 
    Details
    ISSN: 1432-0584
    Keywords: Plasma cell leukemia ; Myelofibrosis Chemotherapy ; Bone marrow biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe a case of plasma cell leukemia associated with myelofibrosis. A 60-year-old woman was admitted due to lumbago and monoclonal hypergammaglobulinemia. Peripheral blood showed about 40% of plasma-cell-like cells. A bone marrow aspiration was dry tap. The patient was diagnosed as having plasma cell leukemia with myelofibrosis by bone marrow biopsy. Plasma cell leukemia as well as myelofibrosis improved with combination chemotherapy using vincristine, pirarubicin, and dexamethasone. However, when plasma cell leukemia became resistant to chemotherapies, myelofibrosis also reappeared. This case strongly suggests the pathogenetic relationship between plasma cell leukemia and myelofibrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695697
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Refractory thrombocytopenia with chromosome 11q23 abnormality (1996)
    Springer
    Annals of hematology 73 (1996), S. 99-102 
    Details
    ISSN: 1432-0584
    Keywords: Key words Myelodysplastic syndromes ; Refractory thrombocytopenia ; Megakaryocytopoiesis ; Chromosome 11q23
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although cytopenia is a common manifestation of myelodysplastic syndrome (MDS), isolated thrombocytopenia is rare. The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia. We describe here a case of RTC associated with chromosome abnormality on 11q23. A 59-year-old man was admitted because of severe thrombocytopenia. A bone marrow examination revealed an increased number of micromegakaryocytes and the absence of normal-sized megakaryocytes without obvious dysplasia in either the myeloid or the erythroid lineage. A remarkable increase of GPIIb/IIIa (CD41a)-positive precursor cells in the bone marrow was observed. Cytogenetic examination detected the chromosome abnormality, an addition on chromosome 11q23. Translocation of the HRX gene was not detectable by Southern blot analysis. The diagnostic problems of isolated thrombocytopenia and possible participation of gene(s) on chromosome 11q23 in megakaryocytopoiesis as well as early hematopoiesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050209
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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