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  • 1
    Electronic Resource
    Electronic Resource
    Cyclic GMP generation mediated by 5-HT-2 receptors via nitric oxide-dependent pathway and its effect on the desensitization of 5-HT-2 receptors in C6 glioma cells (1995)
    Springer
    Journal of neural transmission 100 (1995), S. 27-38 
    Details
    ISSN: 1435-1463
    Keywords: 5-HT-2 receptors ; cGMP generation ; nitric oxide ; desensitization ; C6 glioma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serotonin (5-HT)-2 receptor-mediated cGMP generation was investigated in comparison with calcium (Ca2+) mobilization in C6 glioma cells. 5-HT enhanced cGMP generation, and risperidone and ketanserin potently blocked the response. These results indicate that 5-HT-2 receptors are responsible for the cGMP generation. 5-HT-induced cGMP production was completely abolished by BAPTA, an intracellular Ca2+ chelating agent, or N g -monomethyl-L-arginine (NMMA), a nitric oxide synthase (NOS) inhibitor, suggesting that 5-HT-induced cGMP generation was through nitric oxide (NO)-dependent pathway. 5-HT (10 μM)-elicited Ca2+ mobilization and cGMP generation were reduced to 40 and 15 % after pretreatment with 10 μM 5-HT for 4 hours. NMMA did not modify 5-HT-induced desensitization of either Ca2+ mobilization or cGMP generation, suggesting that NO pathway is independent of the desensitization. The present study has demonstrated the nature of 5-HT-2 receptormediated cGMP generation in C6 glioma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276863
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of acute and chronic administration of dehydroepiandrosterone on (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced wet dog shaking behavior in rats (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 23-33 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Wet dog shaking behavior (WDS) ; dehydroepiandroste-rone (DHEA) ; dexamethasone ; (±)-1-(2 ; 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) ; serotonin-2A (5-HT-2A) receptor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. It has been reported that dehydroepiandrosterone (DHEA) or dehydroepiandrosterone sulfate (DHEA-S) is associated with affective disorders and that pathology of affective disorders are related with dysfunction of serotonin(5-HT)-2A receptor-mediated responses. In this study, we investigated the effect of DHEA on (±)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI), 5-HT-2A receptor agonist, -induced wet dog shaking behavior (WDS) in rats. Acute treatment with DHEA inhibited the DOI-induced WDSs dose dependently. This inhibition was recovered by opioid receptor antagonist, naltrexone. 5-HT-2A receptor-mediated WDSs were desensitized after chronic treatment with DOI, however chronic treatment with DHEA had no effect on this desensitization. Chronic treatment with DHEA had no facilitating effect of chronic dexamethasone treatment on DOI-induced WDSs. These findings may lead the possibility that DHEA has the inhibitory effect of 5-HT-2A mediated signaling pathway via non-genomic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050138
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    Paper (German National Licenses)
    Fulltext
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