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  • 1
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1975)
    Springer
    Acta neuropathologica 32 (1975), S. 209-223 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral Ischemia ; Mongolian Gerbils ; Light Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light microscopic observations were carried out on Mongolian gerbils (Meriones unguiculatus) subjected to a partial cerebral ischemia by occlusion of the left common carotid artery at the neck. About 30% of gerbils developed an ischemic injury in the ipsilateral hemisphere and their brains revealed the following histopathologic features: 1. the changes were related to the intensity (duration) of the ischemic insult and to the time elapsed following release of the occlusion. The ischemic lesions appear to progress after re-establishment of the circulation and this presents one facet of a “maturation” phenomenon which seems to be a general principle applicable to various parameters of ischemic injury. The rate of “maturation” of the lesions is related to the intensity of the ischemic insult, a lesser intensity resulting in longer development of lesions. 2. The changes were either focal or diffuse in character. The former were assumed to be directly related to a vascular involvement; among the latter the topistic distribution of the hippocampal changes suggested a feature of selective vulnerability. 3. An indirect indication of neuronal recovery was surmised from observations on animals sacrificed after different periods following occlusions of the same duration. Also capable of recovery was a “reactive change” observed in the H3 neurons of the hippocampus. This change was characterized by central chromatolysis and resembled the “primäre Reizung” of Nissl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696570
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human Brain Capillary Endothelium: Modulation of K+ Efflux and K+, Ca2+ Uptake by Endothelin (1998)
    Springer
    Neurochemical research 23 (1998), S. 1125-1132 
    Details
    ISSN: 1573-6903
    Keywords: Human brain capillary endothelium ; endothelin-1 ; K+ efflux ; K+ uptake ; Ca2+ uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report describes K+ efflux, K+ and Ca2+ uptake responses to endothelins (ET-1 and ET-3) in cultured endothelium derived from capillaries of human brain (HBEC). ET-1 dose dependently increased K+ efflux, K+ and Ca2+ uptake in these cells. ET-1 stimulated K+ efflux occurred prior to that of K+ uptake. ET-3 was ineffective. The main contributor to the ET-1 induced K+ uptake was ouabain but not bumetanide-sensitive (Na+-K+-ATPase and Na+-K+-Cl− cotransport activity, respectively). All tested paradigms of ET-1 effects in HBEC were inhibited by selective antagonist of ETA but not ETB receptors and inhibitors of phospholipase C and receptor-operated Ca2+ channels. Activation of protein kinase C (PKC) decreased whereas inhibition of PKC increased the ET-1 stimulated K+ efflux, K+ and Ca2+ uptake in HBEC. The results indicate that ET-1 affects the HBEC ionic transport systems through activation of ETA receptors linked to PLC and modulated by intracellular Ca2+ mobilization and PKC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020772422266
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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