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  • Capillary leak syndrome Critical illness Sepsis Blood volume determination Bioelectric impedance Osmotic pressure  (1)
  • Chloride  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Alteration of anion gap during almost total plasma replacement with synthetic colloids in piglets (1999)
    Springer
    Intensive care medicine 25 (1999), S. 1287-1290 
    Details
    ISSN: 1432-1238
    Keywords: Key words Hydroxyethyl starch ; Modified fluid gelatin ; Chloride ; Anion gap ; Acid base ; Saline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In ten piglets (body weight 8.2–11.6 kg), acid base, electrolyte and anion gap changes were investigated during almost total plasma replacement with hydroxyethyl starch (HES) and modified fluid gelatin (GEL) in saline solution using a cell saver autotransfusion technique. During the study, there were only moderate acid base changes, but marked disturbances in anion balance. At study end, the mean chloride concentration was significantly higher (mmol/l: normal values 97–108, HES 116 ± 1.5, GEL 108 ± 1.1, p 〈 0.01) and the mean anion gap was significantly lower in the HES group in comparison to the GEL group (mmol/l: normal values 5–14, HES 3 ± 1.7, GEL 11.9 ± 0.9, p 〈 0.01). It is concluded that plasma replacement with electroneutral HES, but not with negatively charged GEL, can lower the anion gap irrespective of the underlying disease. This can be misleading when the anion gap is used for differential diagnosis of metabolic acidosis in patients after large volume infusion of synthetic colloids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340051059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1252-1258 
    Details
    ISSN: 1432-1238
    Keywords: Capillary leak syndrome Critical illness Sepsis Blood volume determination Bioelectric impedance Osmotic pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: Capillary leakage syndrome (CLS) is a frequent complication in sepsis, characterized by loss of intravasal fluids leading to generalized edema and hemodynamic instability despite massive fluid therapy. In spite of its importance no standardized diagnostic criteria are available for CLS. Design: Prospective clinical study. Setting: 1800-bed university hospital Patients: Six septic shock patients with CLS were compared to six control patients. Measurements and results: CLS was clinically determined by generalized edema, positive fluid balance, and weight gain. Plasma volume was measured by indocyanine green, red blood cell volume by chromium-51 labeled erythrocytes, and colloid osmotic pressure before and 90 min after the administration of 300 ml 20% albumin. Extracellular water (ECW) was measured using the inulin distribution volume and bioelectrical impedance analysis. Red blood cells averaged 20.2±1.0 ml/kg body weight in CLS patients and 23.3±4.1 in controls. ECW was higher in CLS patients than in controls (40.0±6.9 vs. 21.7±3.7 l; p〈0.05). ECW of inulin was correlated with that measured by bioelectrical impedance analysis (r=0.74, p〈0.01). The increase in colloid osmotic pressure over the 90 min was less in CLS patients than in controls (1.1±0.3 vs. 2.8±1.3 mmHg; p〈0.05). Conclusion: These results suggest that measurements of an increased ECW using bioelectrical impedance analysis combined with a different response of colloid osmotic pressure to administration of albumin can discriminate noninvasively between patients with and those without CLS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340000601
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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