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  • Cell & Developmental Biology  (6)
  • Computational Chemistry and Molecular Modeling  (4)
  • Field-flow fractionation  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Polymer analysis by fractionation with on-line light scattering detectors (1982)
    Springer
    Chromatographia 15 (1982), S. 426-432 
    Details
    ISSN: 1612-1112
    Keywords: Polymer analysis ; Molecular weight distribution ; Steric exclusion chromatography ; Field-flow fractionation ; Light scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The classical method for the determination of the molecular weight distribution (MWD) curve of a polymer requires fractionation according to the molecular weight and prior calibration of the separator. It is shown that the use of a dual detection system which includes a molecular mass sensitive detector eliminates the need for prior calibration. The principles of operation of a low-angle light scattering photometer, working as such a detector, are presented, as well as the basic equations for determination of the MWD curve from the elution curve and of the average molecular weights. Then the performances of the light scattering photometer are discussed with special emphasis on the various sources of errors and unaccuracies in these determinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02261602
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  • 2
    Electronic Resource
    Electronic Resource
    Retention in field-flow fractionation with secondary chemical equilibria (1992)
    Springer
    Chromatographia 34 (1992), S. 325-330 
    Details
    ISSN: 1612-1112
    Keywords: Field-flow fractionation ; Secondary chemical equilibria ; Colloidal systems ; Retention theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The application range of field-flow fractionation (FFF) can be extended to low molecular weight solutes, as demonstrated a few years ago by Berthod et al., by taking profit of secondary chemical equilibria (SCE) occurring between the bulk carrier and a retained carrier component. The theory of solute retention in this SCE-FFF method is developed for any value of the solute distribution coefficient and of the retention ratio of the retained carrier component, provided that the Brownian mode of retention applies for this component and that the flow velocity profile is parabolic. This removes some of the limitations of the model previously developed by Berthod and Armstrong and sheds light on the potentialities of the SCE-FFF method for physico-chemical studies about secondary chemical equilibria in colloidal systems. Remaining assumptions in the model are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268363
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of cell-free synchronous uterine flushings and microsurgery on the development of porcine embryos in vitro (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 30 (1991), S. 100-104 
    Details
    ISSN: 1040-452X
    Keywords: Embryo ; Incision ; Zona pellucida ; Trophoblast ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Experiment I was designed to determine if cell-free synchronous uterine flushings contain an embryotoxic substance that is normally screened by the intact zona pellucida. Sixty 4-cell embryos were allocated to three treatment groups: (1) control embryos (n = 20) were cultured in Modified Kreb's Ringer Bicarbonate medium + 10% bovine calf serum (mKRB-BCS), (2) UF embryos (n = 20) were cultured in 80% mKRB-BCS + 20% sterile dialyzed uterine flushings (UF), (3) MicroUF embryos (n = 20) received a microsurgical incision in the zona pellucida and were cultured in 80% mKRB-BCS + 20% UF. Following 72 h in culture at 37°C under a 90% N2, 5% CO2, and 5% O2 atmosphere, the number of nuclei/embryo and the incidence of protrusion of the trophoblast through the zona pellucida (PTZ) were recorded. Addition of UF had no effect on embryo development. A greater (P 〉 .005) proportion of MicroUF embryos exhibited PTZ as compared to UF and control embryos. Experiment II was devised to further characterize the occurrence of PTZ in Micro porcine embryos. Thirty-three 4- to 10-cell embryos and 14 morulae were distributed across two treatments: (1) control embryos (n = 16 and 6, respectively) were cultured as described in Experiment I; and (2) micro embryos were treated similarly to MicroUF embryos in Experiment I but were cultured in mKRB-BCS only. At the onset of PTZ, embryos were immediately fixed and examined. The proportion of embryos exhibiting PTZ was greater (P 〈 .007) for Micro versus control embryos. Both the mean time to PTZ and the number of nuclei present were greater for blastocysts cultured from control as opposed to Micro morulae (P 〈 .0001 and P 〈 .0002, respectively). These results indicate that (a) cell-free synchronous uterine flushings are not detrimental to embryos with incised zonae and (b) microsurgery increases the incidence of and reduces the time to protrusion of the embryo through the zona pellucida in cultured embryos.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080300205
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  • 4
    Electronic Resource
    Electronic Resource
    Franck-Condon factors and squeezed states (1994)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 52 (1994), S. 261-264 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Similarities between the Franck-Condon effect and the concept of Squeezed States have been advanced as a conjecture in the past, or noticed as a marginal fact, without giving a full explanation of how these two important concepts are connected. In this work we outline a unifying formulation that contains as special cases both phenomena. The power of the new approach is shown in a general formula from which all particular cases can be derived. © 1994 John Wiley & Sons, Inc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560520827
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  • 5
    Electronic Resource
    Electronic Resource
    Three decades of collaboration with Hilary Koprowski (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 113 (1982), S. 1-6 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041130504
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  • 6
    Electronic Resource
    Electronic Resource
    Comparison of approximate and exact description of isoviscous flow velocity profile formed in rectangular cross-section channel for field-flow fractionation (1992)
    Springer
    Chromatographia 33 (1992), S. 284-286 
    Details
    ISSN: 1612-1112
    Keywords: Field-flow fractionation ; Three-dimensional flow velocity profile ; Rectangular cross-section channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The shape of the velocity profile established in a carrier liquid flowing in a duct of rectangular cross-section under conditions of isoviscous flow is well known and can be calculated by using an approximate or the exact solution of Navier-Stokes equation. The series evaluated when applying the exact solution were found to converge very rapidly. Consequently, computing can be substantially shortened without loss of accuracy by summing only the first three terms of the series. A fair agreement between the approximate solution of Takahashi and Gill and the exact solution was obtained for all practically applicable aspect ratios of the separation channels used in field-flow fractionation. This conclusion is of interest when calculating various separation parameters in three-dimensional channels for field-flow fractionation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02276196
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  • 7
    Electronic Resource
    Electronic Resource
    Amplitude squared squeezed states in the Fock-Bargmann space (1993)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 46 (1993), S. 515-518 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Squeezed states are normally studied in configuration space or using the Glauber formalism for the coherent states. Here we show that the use of the Fock-Bargmann space can lead to more general solutions, especially in the case of squeezed states associated with the square of field amplitude. The relations that we obtain are completely general and several well-known, approximate results can be obtained as the limit cases of our approach.© 1993 John Wiley & Sons, Inc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560460402
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  • 8
    Electronic Resource
    Electronic Resource
    Expression of transforming growth factor α antisense mRNA inhibits the estrogen-induced production of TGFα and estrogen-induced proliferation of estrogen-responsive human breast cancer cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 156 (1993), S. 497-514 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: To ascertain if 17β-estradiol (E2)-induced proliferation could be attenuated by blocking the expression of endogenous transforming growth factor α (TGFα), estrogen receptor (ER)-positive, estrogen-responsive MCF-7 or ZR-75-1 cells and ER-negative, estrogen-nonresponsive MDA-MB-468 or HS-578T cells were infected with a recombinant amphotropic, replication-defective retroviral expression vector containing a 435 base pair (bp) Apa1-Eco R1 coding fragment of the human TGFα cDNA oriented in the 3′ to 5′ direction and under the transcriptional control of an internal heavy metal-inducible mouse metallothionein (MT-1) promoter and containing the neomycin (neo) resistance gene. E2-stimulated expression of endogenous TGFα mRNA was inhibited by 4-5-fold, and the production of TGFα protein was inhibited by 50-80% when M-1 mass-infected MCF-7 or MZ-1 mass-infected ZR-75-1 cells were treated with 0.75-1 μM CdCl2, whereas in comparably treated parental MCF-7 or ZR-75-1 cells there was no significant effect upon these parameters. E2-stimulated anchorage-dependent growth (ADG) and anchorage-independent growth (AIG) of the M-1 or MZ-1 cells was inhibited by 60-90% following CdCl2 treatment. In contrast, neither the ADG nor AIG of the parental noninfected MCF-7 or ZR-75-1 cells that were maintained in the absence or presence of E2 was affected by comparable concentrations of CdCl2. The ADG and AIG of TGFα antisense MD-1 mass-infected MDA-MB-468 cells that express high levels of endogenous TGFα mRNA were also inhibited by 1 μM CdCl2, whereas the ADG and AIG of MH-1 mass-infected HS-578T cells, a TGFα-negative cell line, were unaffected by CdCl2 treatment. These results suggest that TGFα may be one important autocrine intermediary in regulating estrogen-induced cell proliferation. © 1993 Wiley-Liss, Inc.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041560309
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  • 9
    Electronic Resource
    Electronic Resource
    Quantum chemical structure-activity relationships on β-carbolines as natural monoamine oxidase inhibitors (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 1643-1652 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The electron density and the molecular electrostatic potential of the β-carbolines are studied using ab initio STO-3G wave functions. The analysis was done from the point of view of a previous model built with monoamine oxidase substrates and irreversible inhibitors. The results confirm the usefulness of the model and make it possible to propose new precision to the molecular electrostatic potential patterns needed to have monoamine oxidase inhibitory activity.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230445
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  • 10
    Electronic Resource
    Electronic Resource
    Quantum chemical study of the molecular patterns of MAO inhibitors and substrates (1983)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 23 (1983), S. 1627-1641 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Similarities and differences between mitochondrial monoamine oxidase (MAO) substrates and inhibitors (both A and B types) are considered, studying quantitatively two molecular properties: electron density and molecular electrostatic potential (MEP). The following molecules are considered: substrates: PHEA, BZA, tele-N-methyl-histamine, phenylethanolamine, phenylpropylamine, tryptamine, dopamine, phenoxylethylamine, noradrenaline, serotonin, and p-nitro-phenylethanolamine; inhibitors: Deprenil, Clorgyline, and Lilly 51641 (only the moiety involved in the A-B differentiation is considered). The wave functions needed to calculate the analyzed properties are of ab initio quality, and have been calculated in analogous conformations, all near the energetic minima. Electron densities distributions are qualitatively compared by means of a correlation coefficient defined over the whole space. Otherwise, patterns of the possible zones of electrostatic interactions are described by means of the distances and angles between minima, in order to differentiate MAO-A and MAO-B substrates. The results reproduce efficiently the experimental classification and enable us to predict the type of enzymatic action of molecules not yet experimentally classified.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560230444
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