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  • Atomic photon processes  (1)
  • Cerebrospinal fluid protein  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Serum sickness ; Blood-brain barrier ; Albumin distribution ; Glucose utilization ; Cerebrospinal fluid protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The level of cerebrospinal fluid (CSF) protein is elevated in diseases and disease models that are associated with circulating immune complexes such as serum sickness. Circulatory immune complexes are known to deposit in the basal lamina of fenestrated capillaries and may, as a result, affect both capillary bed and parenchymal function. Since the brain has both fenestrated and unfenestrated capillaries and immune complexes deposit to a varying extent in the fenestrated capillaries in chronic serum sickness, cerebral capillary permeability to protein may be altered in some brain areas and lead to the elevation of CSF proteins. In addition various other cerebrovascular and metabolic functions may also be affected by this condition. In this study either radio-iodinated serum albumin (RISA) or 2-[14C]deoxyglucose (14C-2DG) was intravenously injected into control Wistar rats and Wistar rats with chronic serum sickness; subsequently the tissue levels of radioactivity were measured by quantitative autoradiography in 4 brain areas with fenestrated capillaries and 11 brain areas with unfenestrated capillaries. The 2-min distribution of RISA, which demarcates the volume of circulating plasma in perfused microvessels and is generally proportional to local plasma flow, was the same in control and experimental rats. The passage of RISA from blood into brain over 30 min was negligible in both groups; thus cerebral capillary permeability to albumin was not detectably increased in any of these 15 brain areas by chronic serum sickness. The rate of local cerebral glucose utilization, an indicator of local metabolic and neural activity, was calculated from the 14C-2DG data and was virtually identical in control and experimental rats. These results suggest that chronic serum sickness at this stage has little effect on capillary bed permeability and parenchymal function in most, if not all, brain areas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 9 (1987), S. 71-85 
    ISSN: 0392-6737
    Keywords: Atomic photon processes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Si sono effettuate misure di fluorescenza X indotta da bombardamento di ioni4He di energia compresa tra 0.6 e 5.0 MeV sugli elementi Ag, Cd, In, Sn, Sb, Te e I. Utilizzando un metodo di normalizzazione interna fondato su contemporanee misure di retrodiffusione Rutherford, si sono ottenute le sezioni d’urto assolute per un certo numero di righe X. Da quelle relative alle righeL α ,L γ1,5 eL γ2,3 si sono poi ricavate le sezioni d’urto di ionizzazione per i diversi sottostratiL. Il confronto con le teorie disponibili ha evidenziato la presenza di sensibili disaccordi per tutti i bersagli al di sotto dell’energia incidente di 2.0 MeV e, per Ag, Cd ed In, anche per energie piú elevate, che sono stati attribuiti in parte ai parametri atomici disponibili per i calcoli delle sezioni d’urto ed in parte all’inadeguatezza delle teorie che descrivono il processo di ionizzazione.
    Notes: Summary The X-radiation induced by4He ion impact on Ag, Cd, In, Sn, Sb, Te and I has been investigated for incident energies ranging from 0.6 to 0.5 MeV. Production cross-sections for various X-ray lines have been obtained by an internal normalization method, by means of simultaneous backscattering measurements. From the intensities on theL α ,L γ1,5 andL γ2,3 lines theL-subshell ionization cross-sections have been extracted. Comparison with current theories shows systematic discrepancies for all the targets at incident energy below 2.0 MeV and, for Ag, Cd and In, even in the higher-energy region. These are attributed to deviations in the atomic parameters used in the data analysis as well as to a failure of the ionization theories employed.
    Type of Medium: Electronic Resource
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