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  • 1
    Electronic Resource
    Electronic Resource
    High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease (2000)
    Springer
    Annals of oncology 11 (2000), S. 665-672 
    Details
    ISSN: 1569-8041
    Keywords: autologous peripheral blood progenitor-cell transplantation ; CD34+ cells ; high-dose chemotherapy ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:The use of autologous peripheral blood progenitorcells (PBPC) expedites hematologic recovery and reduces the costs oftransplantation in comparison with autologous bone marrow; however, itsefficacy in patients with Hodgkin's disease has been questioned. We evaluatedthe results of autologous PBPC transplantation in a population of unselectedand uniformly treated patients with primary refractory or relapsed Hodgkin'sdisease. Patients and methods:Forty consecutive adult patients withprimary refractory (n = 7) or relapsed (n = 33) Hodgkin'sdisease received high-dose BEAM (BCNU, etoposide, ara-C, and melphalan)followed by autologous PBPC infusion. Twenty-four patients (60%)received high-dose BEAM as outpatients. Consolidative radiation therapy wasadministered to 14 patients (35%). Results:Thirty-seven patients (92%) achieved a posttransplant complete response. The 3-year progression-free survival (PFS) was69%, and the 3-year overall survival (OS) was 77%, with a medianfollow-up of surviving patients of 28 months. Severe non-hematologictoxicities included gastrointestinal side effects (diarrhea 17%,mucositis 25%), and interstitial pneumonitis (15%). One patientdied of acute transplant-related complications (mortality rate 2.5%).Strong predictors of poor PFS were chemoresistant versuschemosensitive/untested disease (actuarial PFS 89% versus22%, P = 0.0000) and stage IIB–IV versusI–IIA at relapse/progression (86% versus46%, P = 0.005). All five patients with elevated lactatedehydrogenase at the time of transplantation died of their disease. There wasa trend toward worse PFS for patients receiving a higher number of CD34+ cells(≥11 × 106 per kg). Conclusions:High-dose BEAM chemotherapy with autologous PBPCtransplantation is associated with low mortality and results in satisfactoryPFS for patients with primary refractory or relapsed Hodgkin's disease. Thesubset of patients with progressive disease at the time of transplantationperforms poorly and may benefit from alternative strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008396525292
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  • 2
    Electronic Resource
    Electronic Resource
    Real-time estimation of dynamic particle-size distributions in a fluidized bed: Theoretical foundation (1985)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 31 (1985), S. 1202-1212 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Significant noise (random error) is common in an on-line signal when measuring the particle size distribution in a fluidized bed. The application of optimal estimation theory to obtain a filtering algorithm that can rectify such measurements is detailed. Off-line simulation studies demonstrate that the filtering algorithm yields a measure of particle size distribution that is well-behaved, accurate, and able to track in real time as conditions change in the bed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690310718
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of linear distributed-parameter filters to lumped approximants (1986)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 32 (1986), S. 186-194 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Optimal distributed-parameter filters are commonly implemented using approximating lumped Kalman filtering theory. The effect of such an approximation is investigated. A theoretical development shows that there is a loss in the spatial noise correlation for the lumped approximants. Two numerical examples of engineering significance illustrate that one result of this loss is slower filter convergence for the lumped approximants relative to the full distributed-parameter filters.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690320203
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  • 4
    Electronic Resource
    Electronic Resource
    Optimal, real-time monitoring of particle size distribution in a fluidized bed (1986)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 32 (1986), S. 389-396 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A novel method for tracking particle size distribution dynamics in a fluidized bed yields on-line, real-time measurements of particle size distribution that are representative of actual conditions. These measurements are somewhat corrupted with noise (random error), however, and are available to the computer only at discrete time intervals. An optimal filtering algorithm combines the measurements with predictions from an idealized dynamic model to yield particle size distribution estimates that are not only on-line and real-time, but also virtually continuous and well-behaved.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690320305
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    Paper (German National Licenses)
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