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Twenty years-iowa muscle clinic: Reminiscences and prospects (1982)

Zellweger, H. ; Simpson, J. ; Ionasescu, V.

Springer

European journal of pediatrics 138 (1982), S. 17-22

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ISSN: 1432-1076

Keywords: Duchenne muscular dystrophy (DMD) ; Management of DMD ; Genetics of DMD ; Carrier detection ; Newborn screening ; Prenatal diagnosis

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The activities of the last twenty years of the Iowa clinic for neuromuscular diseases are briefly reviewed. Main emphasis in this paper is on management and guidance of the patient with Duchenne muscular dystrophy (DMD) by the families, the school and the public at large. Guidance and treatment given to our patients is briefly described. It is well known that chronic debilitating disease affects not only the patient but the whole family; management of DMD should therefore include the parents and siblings of the patient. Preventability of DMD is illustrated by the experiences in our clinic. The importance of early carrier detection and genetic counseling is stressed. Possible future developments in DMD research are briefly mentioned.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00442321

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Crevice and fretting corrosion of stainless-steel plates and screws (1981)

Brown, S. A. ; Simpson, J. P.

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 15 (1981), S. 867-878

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ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Mechanisms of corrosion at the areas of contact between screw heads and plate holes were investigated using electrochemical potential recording techniques. Static crevice corrosion was studied with plates and screws in isotonic and hypertonic saline solutions (0.9 to 7.2% NaCl). Fretting corrosion was studied in vitro with plates screwed to tubular bone analogs which were subjected to cyclic axial loads, and was studied in vivo with plates screwed on the tibia of sheep. Static tests showed that crevice corrosion does not occur in isotonic saline for periods up to one year, but can occur in hypertonic saline solutions. Dynamic loading tests demonstrated immediate potential changes which were related to the magnitude of the applied load, indicating fretting corrosion due to motion between screw head and plate, both in vitro and in vivo. A mechanism for screw-plate relative motion is proposed. It is hypothesized that corrosion seen in clinically retrieved implants due to fretting corrosion which predisposes the contact area to crevice corrosion attack.

Additional Material: 9 Ill.