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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide (1995)
    Springer
    Diabetologia 38 (1995), S. 24-30 
    Details
    ISSN: 1432-0428
    Keywords: Key words Troglitazone (CS-045) ; insulin secretion ; pancreatic islets ; HIT-T15 cells ; glucose transport ; sulphonylurea receptor ; ATP-sensitive K++ channel.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to elucidate the direct effects of (±)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-yl-methoxy) benzyl]-2,4-thiazolidinedione (Troglitazone), a newly-developed oral hypoglycaemic agent, on pancreatic beta-cell function, in vitro investigation of isolated rat pancreatic islets and a hamster beta-cell line (HIT cell) were performed. Troglitazone stimulates both glucose, and glibenclamide-induced insulin release at a concentration of 10−6 mol/l in these cells but, conversely, inhibits insulin secretion at 10−4 mol/l. Glucose uptake in HIT cells is similarly enhanced by 10−6 mol/l Troglitazone, but is reduced in the presence of 10−4 mol/l Troglitazone. However, a quantitative immunoblot analysis with a specific antibody for GLUT 2 glucose transporter revealed no significant change in GLUT 2 protein in HIT cells with 10−6 mol/l Troglitazone. Specific binding of [3H]-glibenclamide to beta-cell membranes is replaced by Troglitazone in a non-competitive manner, but 10−6 mol/l Troglitazone failed to eliminate ATP-sensitive K++ channel activity. These results suggest that Troglitazone has a putative non-competitive binding site at, or in the vicinity of, the sulphonylurea receptor in rat pancreatic islets and HIT cells and that the dual effect of Troglitazone on insulin secretory capacity is mediated through the modulation of glucose transport activity, possibly due to the modification of intrinsic activity in glucose transporter in pancreatic beta cells by this novel agent. [Diabetologia (1995) 38: 24–30]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050249
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide (1995)
    Springer
    Diabetologia 38 (1995), S. 24-30 
    Details
    ISSN: 1432-0428
    Keywords: Troglitazone (CS-045) ; insulin secretion ; pancreatic islets ; HIT-T15 cells ; glucose transport ; sulphonylurea receptor ; ATP-sensitive K++ channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to elucidate the direct effects of (±)-5-[4-(6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-yl-methoxy) benzyl]-2,4-thiazolidinedione (Troglitazone), a newly-developed oral hypoglycaemic agent, on pancreatic beta-cell function, in vitro investigation of isolated rat pancreatic islets and a hamster beta-cell line (HIT cell) were performed. Troglitazone stimulates both glucose, and glibenclamide-induced insulin release at a concentration of 10−6 mol/l in these cells but, conversely, inhibits insulin secretion at 10−4 mol/l. Glucose uptake in HIT cells is similarly enhanced by 10−6 mol/l Troglitazone, but is reduced in the presence of 10−4 mol/l Troglitazone. However, a quantitative immunoblot analysis with a specific antibody for GLUT 2 glucose transporter revealed no significant change in GLUT 2 protein in HIT cells with 10−6 mol/l Troglitazone. Specific binding of [3H]-glibenclamide to beta-cell membranes is replaced by Troglitazone in a non-competitive manner, but 10−6 mol/l Troglitazone failed to eliminate ATP-sensitive K++ channel activity. These results suggest that Troglitazone has a putative non-competitive binding site at, or in the vicinity of, the sulphonylurea receptor in rat pancreatic islets and HIT cells and that the dual effect of Troglitazone on insulin secretory capacity is mediated through the modulation of glucose transport activity, possibly due to the modification of intrinsic activity in glucose transporter in pancreatic beta cells by this novel agent. [Diabetologia (1995) 38: 24–30]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02369349
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  • 3
    Electronic Resource
    Electronic Resource
    Graft copolymerization by iniferter method; structural analyses of graft copolymer by glass transition temperature (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 40 (1990), S. 1445-1452 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Since 4-vinylbenzyl N,N-diethyldithiocarbamate (VBDC) polymer easily cleaves at the C - S bond and generates benzyl radical, graft copolymerization of methyl methacrylate (MMA) or 4-vinylpyridine (VPy) onto VBDC polymer is easily performed by UV irradiation. The structural analyses of the graft copolymers are performed through glass transition temperature measurements. The graft copolymers of MMA have one Tg and VPy graft copolymers have two Tg's arising from the main and side chains. It becomes clear that the mode of side chains propagation is significantly different for each of the second monomers used.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1990.070400903
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  • 4
    Electronic Resource
    Electronic Resource
    Formose reaction by polymer-supported thiazolium salts (1992)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 30 (1992), S. 2247-2250 
    Details
    ISSN: 0887-624X
    Keywords: polymer catalyst ; formose reaction ; thiazolium salt ; hydrocarbons ; dihydroxy acetone ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Thiazolium salt polymers synthesized by quaternization of 4-(4′-vinylphenyl)thiazole (VPT) polymers with methyl iodide had a highly catalytic activity for “the formose reaction.” Their catalytic activities were comparable to that of a low molecular weight analog, 3-methyl-4-phenylthiazolium iodide (MPTI). In the reaction catalyzed by the polymer catalyst, a main product, dihydroxyacetone (DHA), was detected by gas-liquid chromatography. The polymer catalysts were easily recovered from the reaction mixture and reused with a sustained catalytic activity. © 1992 John Wiley & Sons, Inc.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1992.080301021
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  • 5
    Electronic Resource
    Electronic Resource
    Acyloin condensation in aqueous system by durable polymer-supported thiazolium salt catalysts (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1711-1717 
    Details
    ISSN: 0887-624X
    Keywords: durable catalyst ; thiazolium salt ; aqueous system ; acyloin condensation ; enzyme model ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We characterized three low-molecular-weight thiazolium salt analogues: N-methyl-5-(2′-benzyloxyethyl)-4-methylthiazolium iodide (MBMTI), N-methyl-4-phenylthiazolium iodide (MPTI), and N-methylbenzothiazolium iodide (MBTI). MBMTI, having high-electron density on the thiezolium ring, was found to be a durable thiazolium salt in buffer solution. Then, the polymer-supported thiazolium salt catalyst having MBMTI structure as a catalytic site for acyloin condensation was prepared by the polymerization of the corresponding thiazole monomer and the following quaternization. The polymer catalyst had excellent catalytic activity even in buffer solution, while the corresponding low molecular weight catalyst did not show any activity in aqueous system. Furthermore, the durable polymer catalyst could be reused under the aqueous condition. © 1994 John Wiley & Sons, Inc.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1994.080320913
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  • 6
    Electronic Resource
    Electronic Resource
    Oxygen dissolution and transport in cobaltporphyrin-bound organophosphazene membranes (1993)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 4 (1993), S. 17-20 
    Details
    ISSN: 1042-7147
    Keywords: Poly(organophosphazene) ; Cobaltporphyrin ; Facilitated transport ; Oxygen-separating membrane ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Rubbery poly(organophosphazene)s were synthesized, and were combined with cobaltporphyrin (CoP) which binds molecular oxygen rapidly and reversibly. The apparent oxygen-binding equilibrium constant (Kapp) is in proportion to the physical solubility coefficient of oxygen in the polymer, although the reduced equilibrium and thermodynamic parameters are not dependent on the polymer matrix species. Diffusivity of oxygen via the fixed CoP(DC) is enhanced for poly(organophosphazene) membranes with a larger oxygen diffusion constant. Poly(organophosphazene) membranes with both a large Kapp and DC yield high oxygen permeability.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1993.220040104
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of liquid crystal photoresist (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 52 (1994), S. 577-581 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A thermotropic liquid crystal polymer with photosensitive groups (liquid crystal photoresist), copoly(4-methoxyphenyl) 4′-(2″-acroloyloxy ethoxy) benzoate (MPAEB)-4-vinylbenzyl cinnamate (VBC) was prepared, and its thermal behavior was characterized by a differential scanning calorimetry. The copolymer exhibited a liquid crystal mesophase between approximately 70°C and 120°C. In the mesophase, poly(MPAEB-VBC) (85/15) had a higher photo-crosslinking ability than that at room temperature and at 140°C, where the copolymer exhibited the isotropic phase. It was found that the liquid crystal photoresist had a high crosslinking ability owing to alignment of its photosensitive groups. © 1994 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1994.070520413
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