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  • 1
    Electronic Resource
    Electronic Resource
    Effects of 8-(N-N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) on skinned myocardial fibres of the rat: reversible inhibition of calcium release from the sarcoplasmic reticulum (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 650-655 
    Details
    ISSN: 1432-1912
    Keywords: Skinned fibres ; Myocardium ; Ryanodine receptor ; Ca2+ release ; Sarcoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8), which is reported to inhibit the release of intracellularly stored Ca2+ in skeletal and smooth muscles, were examined in ventricular myocardia of the adult rat. In skinned papillary muscle fibres with functional sarcoplasmic reticulum (SR) preserved, application of 100 or 300 μM TMB-8 during the Ca2+ loading period had no significant effect on the peak tension of subsequent caffeine-induced contraction, but when applied during exposure to caffeine, concentration-dependent reduction of the peak tension was observed. At 1000 μM, TMB-8 reduced the peak tension of caffeine-induced contraction when applied either during Ca2+ loading or during exposure to caffeine. TMB-8 had no substantial influence on the Ca+-tension of skinned fibres without functional SR. In isolated papillary muscle preparations, TMB-8 prolonged the action potential duration and decreased the maximum rate of rise of potential, leading to abolition of contraction at 100 μM. In conclusion, TMB-8 may be a useful pharmacological tool for inhibiting Ca2+ release from SR, but only in skinned myocardial preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170841
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of 8-(N-N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) on skinned myocardial fibres of the rat: reversible inhibition of calcium release from the sarcoplasmic reticulum (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 650-655 
    Details
    ISSN: 1432-1912
    Keywords: Key words Skinned fibres ; Myocardium ; Ryanodine receptor ; Ca2+ release ; Sarcoplasmic reticulum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8), which is reported to inhibit the release of intracellularly stored Ca2+ in skeletal and smooth muscles, were examined in ventricular myocardia of the adult rat. In skinned papillary muscle fibres with functional sarcoplasmic reticulum (SR) preserved, application of 100 or 300 μM TMB-8 during the Ca2+ loading period had no significant effect on the peak tension of subsequent caffeine-induced contraction, but when applied during exposure to caffeine, concentration-dependent reduction of the peak tension was observed. At 1000 μM, TMB-8 reduced the peak tension of caffeine-induced contraction when applied either during Ca2+ loading or during exposure to caffeine. TMB-8 had no substantial influence on the Ca2+-tension of skinned fibres without functional SR. In isolated papillary muscle preparations, TMB-8 prolonged the action potential duration and decreased the maximum rate of rise of potential, leading to abolition of contraction at 100 μM. In conclusion, TMB-8 may be a useful pharmacological tool for inhibiting Ca2+ release from SR, but only in skinned myocardial preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170841
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  • 3
    Electronic Resource
    Electronic Resource
    Inotropic effects of histamine on developing chick heart: release of transmitters from autonomic nerve terminals (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 626-630 
    Details
    ISSN: 1432-1912
    Keywords: Key words Histamine ; Myocardium ; Mast cells ; Autonomic nerve terminals ; Compound 48/80
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Inotropic effects of histamine were examined in isolated ventricular preparations from late embryonic and hatched chick hearts. In 19 day-old embryonic preparations, histamine had little effect on the contractile force. In preparations from 1 to 2 day-old hatched chick, histamine produced a transient decrease in contractile force followed by a sustained increase. The negative and positive responses were antagonized by atropine and propranolol, respectively, but not by histamine antagonists terfenadine, cimetidine or thioperamide. Acetylcholine produced positive inotropic responses in the embryo while negative responses were observed after hatching. In myocardium of hatched chicks, compound 48/80, which releases histamine from mast cells, produced a transient decrease in contractile force followed by a sustained increase with a similar magnitude and time course to the case of exogenously applied histamine. The negative and positive responses were inhibited by atropine and propranolol, respectively, but not by terfenadine, cimetidine or thioperamide, which was similar to the case with the responses to histamine. The present results suggest that histamine, either applied exogenously or released from myocardial store sites, produces negative and positive inotropic responses in hatched chick myocardium which are due to release of acetylcholine and norepinephrine, respectively, from autonomic nerve terminals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171321
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  • 4
    Electronic Resource
    Electronic Resource
    Radical polymerization of 3-cyano-3-ethoxycarbonylpropyl vinyl ether via addition-abstraction mechanism (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 2839-2847 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080261020
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  • 5
    Electronic Resource
    Electronic Resource
    Kinetics of nitrification using a fluidized sand bed reactor with attached growth (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 1683-1702 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The oxidation of ammonium ion to nitrite and nitrate ion (nitrification) has been studied in a laboratory scale fluidized sand bed reactor with attached microbial growth. The undefined population of Nitrobacteracea organisms were immobilized on the sand particles by natural attachment after 2-3 months of adaptation. General balance equations have been formulated for a recycle reactor and oxygenation tank system. Kinetic experiments in the reactor and in a microrespirometer have been analyzed in terms of double Michaelis-Menten rate expression for the nitrogenous reactants and dissolved oxygen. Dynamic simulation of the batch integral reactor system was used to establish the error in the kinetic constant which arose due to assuming differential behavior. Design guidelines have been developed for the oxygen requirements in terms of oxygen transfer coefficients, oxygen enrichment, and liquid recycle rate.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260230803
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  • 6
    Electronic Resource
    Electronic Resource
    Modeling of experiments on biofilm penetration effects in a fluidized bed nitrification reactor (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 25 (1983), S. 1841-1861 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A four-component, diffusion-reaction model with double Michaelis-Menten kinetics was used to describe the experimental data obtained from a laboratory biofilm, fluidized-bed nitrification reactor. Theory and experiment demonstrated that the stoichiometric ratio (3.5 mg O2/mg NH4+-N) can be employed as a criterion to determine whether the limiting substrate is oxygen or ammonia. For the present work, in the range of concentrations where limitation occurred, 4 mg/L NH4+-N and 14 mg/L O2, the ratio of oxygen to ammonia in the bulk liquid determined which substrate was penetration-limiting - O2 if 〈3.5 and NH4+ if 〉 3.5. Halforder kinetics with respect to the limiting substrate described the apparent overall rates. Simulations provided biofilm concentration profiles which demonstrated the role of the oxygen-ammonia ratio. Experiments indicated that, generally, high NO2- concentrations can be expected. These depend on the residence time, biofilm area, and oxygen concentration. This dependency was investigated with the model, as was the parametric sensitivity with respect to the saturation constants. Particularly important for the NO2- levels were the ratios of the saturation constants for oxygen.
    Additional Material: 23 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260250713
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  • 7
    Electronic Resource
    Electronic Resource
    Kinetics of biofilm nitrification (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 24 (1982), S. 669-689 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The reaction rates (rNH4+ and rNO2-) in the two-step nitrification reaction were measured in a fluidized-sand-bed biofilm reactor under a range of steady-state conditions with respect to bulk NH4+, NO2-, and O2 concentrations. It was shown from theory and experiment that under low NH4+ concentration conditions, if the O2/NH4+ concentration ratio in the bulk liquid is less than the stoichiometric coefficient (3.4 mg/mg), then oxygen will be rate limiting. In all experiments rNO2- decreased more than rNH4+ under low oxygen conditions. This resulted in high NO2- effluent concentrations under low residence time conditions. The influence of the oxygen penetration effects on the relative values of rNH4+ and rNO2- was experimentally shown to be caused either by the Nitrobacter location in the inner biofilm regions or by a Km effect for oxygen. Theoretical support of these findings was provided by a differential diffusion-reaction model which was used to simulate the experimental results.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260240311
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of alicyclic polyimides based on cyclobutane ring dianhydride and aromatic diamine (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 54 (1994), S. 1297-1304 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Films of alicyclic polyamic acid and polyimide containing cyclobutane ring in dianhydride moiety and aromatic ring with p- or m-linkages in diamine moiety were characterized by infrared (IR) spectroscopy, dynamic viscoelasticity, differential-scanning calorimetry (DSC), density, and wide-angle X-ray diffraction analyses. Partially and fully imidized polyimides were obtained by varying the imidization temperature, e.g., 150°C, 250°C, and 350°C. It was found from the results of IR spectra, dynamic viscoelasticity, and DSC measurements that the imidization of alicyclic polyamic acid was reduced at about 150°C and needed a higher imidization temperature than aromatic polyamic acid. Alicyclic polyimide with m-linkage in the diamine moiety had a higher density and a much more ordered structure than with p-linkage. © 1994 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1994.070540911
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  • 9
    Electronic Resource
    Electronic Resource
    Radical homopolymerization and copolymerizations of ring-methoxy substituted α-cyanostyrenes (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Polymer International 38 (1995), S. 199-203 
    Details
    ISSN: 0959-8103
    Keywords: radical polymerization ; cyanostyrene ; captodative substituted monomer ; captodative effect ; thermal properties of captodative polymers ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Radical homopolymerization and copolymerizations of ring-methoxy substituted α-cyanostyrenes were studied using benzoyl peroxide and dimethyl 2,2′-azobisisobutylate at 60°C. It was found that the cyanostyrenes containing 2-methoxy cyanostyrene gave homopolymer in moderate yield and they were also copolymerized with vinyl monomers such as styrene and vinyl acetate. The relative reactivity of the cyanostyrenes towards a polystyryl radical (1/r2) in the copolymerization of cyanostyrenes (M1) and styrene (M2) was correlated with the Hammett and Taft substituent constants of the methoxy groups and the 13C NMR chemical shift of the β-carbon of the cyanostyrenes. The enhancement of the radical polymerization reactivity by introducing a nitrile group in the captodative α-position of styrene was considered to be due to the suppression of the termination reaction and the activation of the propagation reaction. In addition, thermal properties such as glass transition and degradation temperatures of the cyanostyrene polymers obtained were also examined.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pi.1995.210380213
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  • 10
    Electronic Resource
    Electronic Resource
    Capillary electrophoretic monitoring for C-terminal fragment identification (1991)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 14 (1991), S. 491-492 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoretic monitoring ; Rapid C-terminal fragment identification ; Anhydrotrypsin affinity column ; Lys-C-endoproteinase digestion ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240140716
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