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  • 1
    Electronic Resource
    Electronic Resource
    The role of middle ear effusions and epidermal growth factor in cholesteatoma formation in the gerbilline temporal bone (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 428-432 
    Details
    ISSN: 1434-4726
    Keywords: Mongolian gerbil ; Cholesteatoma ; Middle ear effusion ; Otitis media with effusion ; Epidermal growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the process of aural cholesteatoma formation, we used gerbilline temporal bones to examine histologically the early stages of spontaneous cholesteatomas associated with experimentally induced otitis media with effusion (OME) following electric cauterizations of the eustachian tube. Epidermal growth factor (EGF) was then localized immunohistochemically in the pars flaccida of normal ears and the forming spontaneous cholesteatomas. Findings in the ears with the early spontaneous cholesteatomas were effusion inside the pars flaccida and hypertrophy and hyperkeratosis of the pars flaccida. Findings in the ears with experimental OME involved an effusion in the whole middle ear cavity as well as hypertrophy and hyperkeratosis in both the pars flaccida and pars tensa. The incidence of ear drum changes was higher in the experimental OME group than in control animals without cauterization. EGF was localized in the mucous layer of normal drums, the mucous layer and lamina propria of drums with hypertrophy alone, and all lalers in drums with hypertrophy and hyperkeratosis. EGF was especially positive in the cytoplasms of transformed cuboidal cells. These findings suggest that EGF within the transformed mucous layer may play an important role as a biochemical factor in developing cholesteatomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167314
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Epithelial migration on the tympanic membrane and external canal (1986)
    Springer
    European archives of oto-rhino-laryngology and head & neck 243 (1986), S. 39-42 
    Details
    ISSN: 1434-4726
    Keywords: Epithelial migration ; Tympanic membrane ; External canal ; Pathology ; Cholesteatoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ink dot staining method was used to examine epithelial migration in normal ears, in pathologic tympanic membranes, and in external auditory canal cholesteatoma. The direction of the epithelial migration was found to coincide with that of the vessels in normal ears. This suggested that epithelial migration was controlled by the vessels which supply the epidermal layer of the tympanic membrane. In pathologic tympanic membranes and external auditory canal cholesteatomas, epithelial migration was disturbed to various degrees and depended on the local conditions. In these pathologic conditions, the tympanic membrane showed less vascularization. Based on our findings, we believe that a poor blood supply is the major etiologic factor for the epithelial migratory disturbances of the tympanic membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457906
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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