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  • 1
    Electronic Resource
    Electronic Resource
    The clinical features and pathogenesis of myringitis granulosa (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 224-229 
    Details
    ISSN: 1434-4726
    Keywords: Myringitis granulosa ; Pathogenesis ; Epithelial migration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Myringitis granulosa is not a rare pathologic condition of the tympanic membrane. However, the condition can be misdiagnosed as chronic suppurative otitis media, since intermittent purulent discharge is the commonest symptom in both disorders. Although the clinical features of myringitis granulosa have been well described by several authors, its pathogenesis is still obscure. In this study, 40 cases of myringitis granulosa were examined in detail to clarify the clinical features and the pathogenesis present. No drum perforations, no hearing impairments and normal X-ray findings indicated that myringitis granulosa had no relation to chronic suppurative otitis media. The other areas of the affected tympanic membrane, except for the site of granulation, showed such pathologic conditions as atrophy, clouding and calcifications. In these pathologic tympanic membranes, epithelial migration was disturbed to a high degree. We suggest that the granulation process on the tympanic membrane should be divided into two stages: (1) injury reaching the lamina propria of the tympanic membrane; and (2) disturbed epithelization of the tympanic membrane. The disturbance of epithelial migration of the tympanic membrane occurs with both stages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463932
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  • 2
    Electronic Resource
    Electronic Resource
    Epithelial migration in the healing process of tympanic membrane perforations (1990)
    Springer
    European archives of oto-rhino-laryngology and head & neck 247 (1990), S. 352-355 
    Details
    ISSN: 1434-4726
    Keywords: Tympanic membrane ; Perforation ; Healing process ; Epithelial migration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The healing process in 10 human tympanic membrane perforations after trauma and 20 myringotomies was observed under the microscope and was photographed. The movement of the healing process was from the central portion of the perforation to the periphery and followed the same direction as the drum's epitehlial migration. At the central portion of the perforation's margin, the keratin layer proceeded to the periphery and was followed by the epidermal cell layer. Only slight movement was observed at the peripheral portion of the perforation. Histopathological examination confirmed these observations. These findings demonstrate that epithelial migration on the tympanic membrane plays a great role in the healing of a perforation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179005
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  • 3
    Electronic Resource
    Electronic Resource
    Significance of tubal resection in surgical treatment of middle ear carcinoma (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 208-211 
    Details
    ISSN: 1434-4726
    Keywords: Middle ear cancer ; Eustachian tube ; Internal carotid artery ; Temporal bone resection ; Tumor spread
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We successfully carried out total en bloc resection of squamous cell carcinoma of the middle ear in two patients. Both patients have been free of the disease for 32–39 months. In one of the cases, the eustachian tube was resected totally with the temporal bone. Postoperative histopathological examination proved tumor invasion into the cartilaginous part of the tube. We would like to emphasize the significance of total resection of the eustachian tube when neoplastic invasion into the tube is highly suspected. Axial computed tomography is of great value for preoperative evaluation of such invasion. Anterior mobilization of the carotid artery from the carotid canal facilitates resection of the petrous apex and should be done after management of the eustachian tube. The carotid canal is best exposed ventrally, since lateral exposure is at high risk for injuring the bony part of the eustachian tube and may possibly disseminate tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00879276
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  • 4
    Electronic Resource
    Electronic Resource
    Conservative treatment of Bell's palsy with steroids and dextran-pentoxiphylline combined therapy (1991)
    Springer
    European archives of oto-rhino-laryngology and head & neck 248 (1991), S. 147-149 
    Details
    ISSN: 1434-4726
    Keywords: Bell's palsy ; Steroids ; Steroid ; Dextran ; Pentoxiphylline combined therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 1980, Stennert proposed for the treatment of Bell's palsy an infusion therapy consisting of initially high dosages of steroids in combination with low-molecular dextran and pentoxiphylline. Excellent results were reported as a consequence of administering this treatment scheme. This “steroid-dextran” medication was modified (SD therapy) and administered in 172 cases of Bell's palsy. The results were compared with those of a group of 59 patients who had been treated with orally administered low-dose steroids in combination with vasodilators, adenosine triphosphate and vitamins. All patients with incomplete palsies recovered completely, regardless of the mode of treatment. In cases of complete palsy, 87% of patients recovered completely when treated with SD therapy. In contrast, 68% of the patients treated with orally administered steroids recovered completely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178925
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  • 5
    Electronic Resource
    Electronic Resource
    The role of middle ear effusions and epidermal growth factor in cholesteatoma formation in the gerbilline temporal bone (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 428-432 
    Details
    ISSN: 1434-4726
    Keywords: Mongolian gerbil ; Cholesteatoma ; Middle ear effusion ; Otitis media with effusion ; Epidermal growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the process of aural cholesteatoma formation, we used gerbilline temporal bones to examine histologically the early stages of spontaneous cholesteatomas associated with experimentally induced otitis media with effusion (OME) following electric cauterizations of the eustachian tube. Epidermal growth factor (EGF) was then localized immunohistochemically in the pars flaccida of normal ears and the forming spontaneous cholesteatomas. Findings in the ears with the early spontaneous cholesteatomas were effusion inside the pars flaccida and hypertrophy and hyperkeratosis of the pars flaccida. Findings in the ears with experimental OME involved an effusion in the whole middle ear cavity as well as hypertrophy and hyperkeratosis in both the pars flaccida and pars tensa. The incidence of ear drum changes was higher in the experimental OME group than in control animals without cauterization. EGF was localized in the mucous layer of normal drums, the mucous layer and lamina propria of drums with hypertrophy alone, and all lalers in drums with hypertrophy and hyperkeratosis. EGF was especially positive in the cytoplasms of transformed cuboidal cells. These findings suggest that EGF within the transformed mucous layer may play an important role as a biochemical factor in developing cholesteatomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167314
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  • 6
    Electronic Resource
    Electronic Resource
    Epithelial migration on the tympanic membrane and external canal (1986)
    Springer
    European archives of oto-rhino-laryngology and head & neck 243 (1986), S. 39-42 
    Details
    ISSN: 1434-4726
    Keywords: Epithelial migration ; Tympanic membrane ; External canal ; Pathology ; Cholesteatoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ink dot staining method was used to examine epithelial migration in normal ears, in pathologic tympanic membranes, and in external auditory canal cholesteatoma. The direction of the epithelial migration was found to coincide with that of the vessels in normal ears. This suggested that epithelial migration was controlled by the vessels which supply the epidermal layer of the tympanic membrane. In pathologic tympanic membranes and external auditory canal cholesteatomas, epithelial migration was disturbed to various degrees and depended on the local conditions. In these pathologic conditions, the tympanic membrane showed less vascularization. Based on our findings, we believe that a poor blood supply is the major etiologic factor for the epithelial migratory disturbances of the tympanic membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00457906
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  • 7
    Electronic Resource
    Electronic Resource
    Operative Technik für die Sprachanbildung nach Kehlkopftotalexstirpation (1978)
    Springer
    European archives of oto-rhino-laryngology and head & neck 219 (1978), S. 373-373 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463829
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