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  • 1
    Electronic Resource
    Electronic Resource
    Epidermal growth factor receptors and epidermal growth factor-like activity in colorectal mucosa, adenomas and carcinomas (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 518-523 
    Details
    ISSN: 1432-1440
    Keywords: Epidermal growth factor ; EGF ; Transforming growth factor ; EGF-receptor ; Carcinogenesis ; Colon ; Rectum ; Colonic adenoma ; Colonic carcinoma ; Familial polyposis coli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The epidermal growth factor (EGF) and alpha-tumor growth factor are mitogenic proteins which bind to the EGF-receptor and may play a role in carcinogenesis or tumor progression. Our study investigated whether colorectal carcinomas and adenomas express altered levels of EGF-receptors or overproduce EGF-like activity by comparing histologically normal mucosa to carcinomas resected from the same patients. EGF-receptors were characterized by radioligand binding studies. Carcinomas contained unchanged or decreased levels of EGF-receptors in 13/16 and moderately increased levels in 3/16 patients as compared to normal mucosa. Adenomas obtained from 2 patients with familial polyposis coli and from a third patient with a coincident carcinoma had similar numbers of EGF-receptors as normal mucosa. EGF-like growth factors, in contrast, were significantly elevated in carcinoma extracts as compared to extracts from normal mucosa of the same patients. Adenomas did not contain elevated levels of EGF-like activity. We conclude that increased expression of EGF-receptors is infrequent in colonic adenocarcinomas. Increased production of EGF-like growth factors may frequently occur but seems to be associated with tumor progression rather than with premalignant lesions as represented by adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719776
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Wirkung von Aprotinin Blutverlust und Gerinnungsparameter bei orthotoper Lebertransplantation: Eine klinisch-experimentelle, prospektive und randomisierte Doppelblindstudie (1997)
    Springer
    Der Anaesthesist 46 (1997), S. 294-302 
    Details
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Lebertransplantation ; Aprotinin ; Transfusionsbedarf ; Gerinnungsparameter ; Key words Liver transplantation ; Aprotinin ; Transfusion requirements ; Coagulation parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The effect of aprotinin (2000000 IU as a bolus +500000 JU/h until the end of the operation) on transfusion requirements and coagulation parameters in orthotopic liver transplantation (study group: n=9; placebo group: n=9) was investigated in a randomised, double-blind study. Coagulation parameters were monitored intraoperatively using a mobile laboratory. In contrast to the published results, no effect on transfusion requirements could be demonstrated. However, aprotinin showed a positive effect on some coagulation parameters in the reperfusion phase. The mechanism appeared to be inhibition of the contact activation of the intrinsic system with less thrombin generation in the study group.
    Notes: Zusammenfassung In einer randomisierten Doppelblindstudie wurde der Effekt von Aprotinin (2000000 KIE als Bolus+500000 KIE/h bis zum Ende der Operation, Verumgruppe n=9; Plazebogruppe n=9) auf Gerinnungsparameter und Transfusionsbedarf bei orthotoper Lebertransplantation untersucht. Alle Patienten wurden mit Hilfe eines fahrbaren Gerinnungslabors intraoperativ optimal überwacht. Im Gegensatz zu anderen Arbeitsgruppen fand sich unter diesen Bedingungen für den Transfusionsbedarf kein signifikanter Unterschied zwischen Verum- und Plazebogruppe. Dagegen beobachteten wir einen günstigen Effekt des Proteinaseninhibitors auf verschiedene Gerinnungsparameter, besonders in der Reperfusionsphase. Offensichtlich wird die Kontaktaktivierung des intrinsischen Gerinnungssystems, die durch geschädigte Gefäße des transplantierten Organs eingeleitet wird, durch Aprotinin gehemmt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001010050404
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    Paper (German National Licenses)
    Fulltext
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