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  • Antitumor effect  (1)
  • Curved nail  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Treatment of the femoral shaft fracture with a curved heat-treated COP clover-leaf nail (1979)
    Springer
    International orthopaedics 3 (1979), S. 203-210 
    Details
    ISSN: 1432-5195
    Schlagwort(e): Femoral shaft fracture ; Curved nail
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Le clou droit intra-médullaire, d'usage courant, comporte un certain nombre de limitations et d'inconvénients. A la suite d'études radiographiques et métallurgiques, nous avons mis au point un nouveau clou courbe, en feuille de trèfle à la coupe, fabriqué avec un nouvel alliage nickel-chrome-cobalt (COP). Le clou est incurvé, avec un sillon sur sa face convexe et un rayon de courbure de 115 cm, correspondant à la convexité anatomique du fémur humain. Ce clou a été utilisé de façon satisfaisante depuis 1971, car il procure non seulement une fixation interne plus stable, mais permet également la synthèse des fractures situées au-dessous du tiers moyen de la diaphyse.
    Notizen: Summary The commonly used straight intramedullary nail has certain limitations and disadvantages. Following radiographic and metallurgical studies we have developed a curved heat-treated clover-leaf nail using a newly developed precipitation hardening stainless steel (COP). The nail is bent with a slot on the convex side and the radius of curvature is 115 cm which corresponds to the anatomical antero-lateral convexity of the human femur. The nail has been satisfactory in clinical use since 1971 and has provided not only more stable internal fixation but also allowed fixation of fractures beyond the middle third of the shaft.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00265713
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Antitumor and antimetastatic effects of interleukin 12 (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. S22 
    Details
    ISSN: 1432-0843
    Schlagwort(e): Key words Interleukin 12 (IL-12) ; Interferon-γ (IFN-γ) ; Antitumor effect ; Antimetastatic effect
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Interleukin 12 (IL-12) has a pivotal role in controlling cell-mediated immunity through a number of important biological activities, such as secretion of interferon-γ (IFN-γ). In this review, we report our recent results regarding the antitumor and antimetastatic effects of IL-12. Five intraperitoneal injections of recombinant IL-12 (rIL-12) into mice bearing subcutaneous tumors (CSA1M fibrosarcoma) induced complete tumor regression, irrespective of whether tumors were at early or late stages of growth. Furthermore, IL-12-treated mice that had rejected the primary tumor exhibited complete resistance to rechallenge with the same tumor but did not reject a second syngeneic tumor. Immunohistochemical analyses following IL-12 treatment revealed that CD4+ and CD8+ T-cells had infiltrated the tumor. More importantly, IFN-γ mRNA expression was observed in fresh tumor masses from tumor-bearing mice receiving IL-12 treatment. The importance of IFN-γ was further demonstrated by the observation that systemic administration of anti-IFN-γ monoclonal antibody prior to IL-12 treatment completely abrogated the antitumor effect of IL-12. We next investigated the ability of rIL-12 to modulate the outgrowth of metastatic tumor cells in an ovarian carcinoma (OV-HM) model. This aggressive tumor showed rapid growth of the primary tumor mass, a high incidence of metastases to the lung and lymph nodes, and invasion from the primary subcutaneous site into the peritoneal cavity. At approximately 1 month after tumor implantation, primary tumors in animals without palpable lymph nodes were surgically resected. When examined 2 months later, most animals had developed lymph node and lung metastases. In contrast, rIL-12 injections following tumor resection inhibited the development of metastases in both the lung and lymph nodes. Even in mice showing signs of lymph node metastases or invasion of the abdominal wall before primary tumor resection, rIL-12 administration following tumor resection prevented further invasion into the peritoneal cavity and metastatic tumor cell growth in the lung. Our results demonstrate that administration of rIL-12 to tumor-bearing mice results in tumor regression through mechanisms involving efficient IFN-γ production by antitumor T-cells at tumor sites in situ and the establishment of a tumor-specific protective immune response. The results also indicate that IL-12 can induce a curative immune response in the face of an aggressive micrometastasizing tumor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002800051032
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