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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and metabolism of cyclophosphamide administered after total body irradiation of bone marrow transplant recipients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 521-523 
    Details
    ISSN: 1432-1041
    Keywords: Cyclophosphamide ; Pharmacokinetics ; 4-Hydroxycyclophosphamide ; Bone marrow Transplantation ; Total body irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary High-dose cyclophosphamide is used immediately after total body irradiation (TBI) in conditioning for bone marrow transplantation (BMT). Possible interactions of the two treatment modalities were sought by measuring the blood pharmacokinetics of CP and 4-hydroxy-cyclophosphamide (4-HOCP) in patients undergoing BMT. There was a non-significant trend to a shorter half-life of CP compared to reported values. Exposure to 4-HOCP, the major metabolite of CP, did not appear to be altered by prior TBI of the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315233
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative study on human pharmacokinetics of activated ifosfamide and cyclophosphamide by a modified fluorometric test (1981)
    Springer
    Journal of cancer research and clinical oncology 100 (1981), S. 95-104 
    Details
    ISSN: 1432-1335
    Keywords: Ifosfamide ; Cyclophosphamide ; Human pharmacokinetics of activated metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The activated metabolites of ifosfamide and cyclophosphamide (4-hydroxy-ifosfamide and 4-hydroxy-cyclophosphamide) were analysed fluorometrically by condensation of liberated acrolein with m-aminophenol yielding 7-hydroxychinolin. Interfering fluorescence of blood and urine was eliminated by extraction with dichlormethane and determination of blanks in which the liberated acrolein reacted with hydrazine to non-fluorescent pyrazoline. The modified test proved effective in identifying low levels of activated metabolites in man. After i.v. injection of 20 mg/kg cyclophosphamide or ifosfamide peak levels of activated cyclophosphamide (4.7 nmol/ml) and the area under the curve (c·t=16.7 nmol·ml/h) showed mean values three times higher than those found for activated ifosfamide. One per cent of the applied dosis of cyclophosphamide vs. 0.3% of ifosfamide was excreted as activated metabolites. Due to the high stability of activated cyclophosphamide and ifosfamide in urine a low liberation rate of acrolein was found, the concentration of which in urine was below 0.5 nmol/ml. Acrolein, which was directly liberated from activated cyclophosphamide or ifosfamide, does not seem to play an important role in the urotoxicity of these cytostatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405906
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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