ISSN:
1420-908X
Keywords:
Collagen
;
Arthritis
;
Cyclosporin and hyaluronan
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01793217
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