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  • 1
    Electronic Resource
    Electronic Resource
    Delayed-type skin reaction to 2,4-dinitrophenylated epidermal cells in guinea pigs with contact sensitivity to 2,4-dinitrochlorobenzene (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 236-240 
    Details
    ISSN: 1432-069X
    Keywords: 2,4-Dinitrochlorobenzene (DNCB) ; Contact sensitivity ; Epidermal cell ; Delayed-type skin reaction ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Contact sensitivity (CS) induced by hapten has been thought to be analogous to delayed-type hypersensitivity, such as the Mantoux reaction, because of outstanding similarities between the two phenomena. It can be suggested that animals with CS respond also to intradermal injection of the conjugate of hapten and protein as well as to epicutaneous application of hapten. However, evidence against this has been reported. In the present experiments, delayed-type skin reaction (DSR) was successfully obtained in JY1 strain guinea pigs sensitized by painting the skin with 2,4-dinitrochlorobenzene using in vitro dinitrophenylated epidermal cell suspension (DNP-EC) as antigen for a delayed intradermal test. The experiment using anti-Ia alloantiserum and complement showed that the elicitation of DSR is due to the presence of Ia-positive cells (presumably Langerhans cells) among DNP-ECs. The delayed intradermal test with the conjugates such as haptenated ECs in the animals with CS is considered to be an experimentally useful way of analysing the antigen in the sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417321
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  • 2
    Electronic Resource
    Electronic Resource
    Role of cytokines in controlling connective tissue gene expression (1994)
    Springer
    Archives of dermatological research 287 (1994), S. 115-121 
    Details
    ISSN: 1432-069X
    Keywords: Cytokines ; Fibroblasts ; Connective tissue ; Gene expression ; Tumour necrosis factor-α (TNF-α)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recently, the role of cytokines in controlling gene expression of connective tissue components has been increasingly emphasized. Many cytokines have been shown to have specific effects on gene expression of connective tissue components, and the roles of cytokines in controlling connective tissue metabolism during wound healing and in fibrosis have increasingly been discussed. In this article, the effects of cytokines on regulation of gene expression of connective tissue components, especially of type I collagen were described. We analysed transcriptional control of the α1(I) collagen gene by TNF-α by means of DNA mediated transfection experiments using recombinant plasmids in which the promoter region of the human α1(I) collagen had been fused to the chloramphenicol acetyl-transferase (CAT) gene, in human dermal fibroblasts. It was found that TNF-α reduced α1(I) collagen transcription through at least up to −107 bp upstream of the human α1(I) collagen promoter gene in dermal fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370729
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    Paper (German National Licenses)
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