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  • 1
    Electronic Resource
    Electronic Resource
    Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin (1984)
    Springer
    Archives of dermatological research 277 (1984), S. 60-64 
    Details
    ISSN: 1432-069X
    Keywords: Histamine ; Collagen synthesis ; Fibroblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast-like cells derived from guinea-pig skin were cultured for 3 h in the presence of various concentrations of histamine. The total protein synthesized was determined by the incorporation of radioactive proline, and the collagenous protein synthesized was measured by the incorporation of labeled hydroxyproline in the cell layer and medium. Synthesis of both total and collagenous protein increased in the presence of histamine in the concentration range of 101–103 μg/ml. The ratio of collagen to total protein synthesized also increased at these concentrations. However, in no case was an increase found when H1 antagonist (chlorpheniramine) and H2 antagonist (cimetidine) were added with the histamine. DNA synthesis was not affected by histamine at the concentrations used. These results suggest that histamine increases the synthesis of collagen by fibroblast-like cells through H1 and H2-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406482
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Increased number of mast cells accompany enhanced collagen synthesis in linear localized scleroderma (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 288-290 
    Details
    ISSN: 1432-069X
    Keywords: Mast cells ; Linear localized scleroderma ; Collagen synthesis ; Histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431065
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The suppressive effect of tape-stripping treatment of guinea-pig skin on the induction of contact sensitivity by intradermal injection of haptenated epidermal cells (1985)
    Springer
    Archives of dermatological research 278 (1985), S. 102-106 
    Details
    ISSN: 1432-069X
    Keywords: Tape stripping ; Contact sensitivity ; DNCB ; Dinitrophenylated epidermal cell ; Immunological suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Contact sensitivity (CS) to 2,4-dinitrochlorobenzene (DNCB) was produced in inbred JY1-strain guinea pigs by the intradermal injection of epidermal cells (ECs) prepared from DNCB-painted skin (DNP-ECs). When the site of DNP-EC-induced CS was pretreated by tape stripping, the rate and intensity of the challenge reactions to DNCB were diminished. The ability of DNP-ECs to induce CS returned to normal when normal peritoneal macrophages together with DNP-ECs were administered into the stripped skin. Normal ECs had a similar effect. Using either anti-Ia antiserum and complement or allogeneic ECs (strains 2 and 13), Ia-positive cells among the ECs (presumably Langerhans cells) were found to be essential for the recovery of CS. Tape-stripping treatment also resulted in the development of immunological tolerance, as assessed by subsequent painting with a sensitizing dose of DNCB. These findings suggest that the immunological function of the mononuclear-phagocyte system in the dermis may be impaired when the epidermal surface is markedly disturbed by tape-stripping treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409215
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The distribution of 2,4-dinitrophenyl groups in guinea pigs following feeding of 2,4-dinitrochlorobenzene (1985)
    Springer
    Archives of dermatological research 278 (1985), S. 97-101 
    Details
    ISSN: 1432-069X
    Keywords: Contact sensitivity ; Tolerance ; Feeding ; DNCB ; Antigen distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunofluorescent technique using anti-DNP antibody was employed to investigate the distribution of 2,4-dinitrophenyl (DNP) groups in various tissues following the feeding of 125 mg/kg 2,4-dinitrochlorobenzene (DNCB)-ethanol to guinea pigs that had been starved for 1 day. DNP groups were detected in the areas corresponding to the cytoplasm and the cell membrane of the epithelium in the upper gastrointestinal tract as well as on the cells of mesenteric lymph nodes, Payer's patches, the spleen, and peripheral blood. These results are discussed in relation to the mechanism of tolerance induction produced by the feeding of haptens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409214
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    Paper (German National Licenses)
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