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  • 1
    Electronic Resource
    Electronic Resource
    Cerebromicrovascular endothelial permeability (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 329-334 
    Details
    ISSN: 1432-0533
    Keywords: Cerebromicrovascular endothelium ; Arachidonic acid ; Indomethacin ; Dexamethasone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Permeability of cerebromicrovascular endothelium has been investigated in a new model of cultured cells. The endothelial cells are grown on dextran microcarriers and constitute a barrier for trypan blue (TB) binding to the dextran beads. Changes in the permeability of microcarrier-cultured endothelium have been investigated during the exposure of cells to arachidonic acid or substances involved either in arachidonate metabolism or stimulation of cAMP. The results demonstrate enhanced TB passage through the endothelial barrier during exposure to high concentrations of arachidonic acid and indomethacin, but not to ibuprofen. The effect of indomethacin could be prevented by pretreatment with dexamethasone. Dexamethasone alone did not influence the barrier. Forskolin, a drug which stimulates the catalytic unit of adenylate cyclase, did not affect the endothelial permeability to TB. These findings support the contention that substances derived from a disturbed cellular membrane contribute to the altered blood-brain barrier function found under pathological conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687209
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental cerebral ischemia in Mongolian gerbils (1975)
    Springer
    Acta neuropathologica 32 (1975), S. 209-223 
    Details
    ISSN: 1432-0533
    Keywords: Cerebral Ischemia ; Mongolian Gerbils ; Light Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Light microscopic observations were carried out on Mongolian gerbils (Meriones unguiculatus) subjected to a partial cerebral ischemia by occlusion of the left common carotid artery at the neck. About 30% of gerbils developed an ischemic injury in the ipsilateral hemisphere and their brains revealed the following histopathologic features: 1. the changes were related to the intensity (duration) of the ischemic insult and to the time elapsed following release of the occlusion. The ischemic lesions appear to progress after re-establishment of the circulation and this presents one facet of a “maturation” phenomenon which seems to be a general principle applicable to various parameters of ischemic injury. The rate of “maturation” of the lesions is related to the intensity of the ischemic insult, a lesser intensity resulting in longer development of lesions. 2. The changes were either focal or diffuse in character. The former were assumed to be directly related to a vascular involvement; among the latter the topistic distribution of the hippocampal changes suggested a feature of selective vulnerability. 3. An indirect indication of neuronal recovery was surmised from observations on animals sacrificed after different periods following occlusions of the same duration. Also capable of recovery was a “reactive change” observed in the H3 neurons of the hippocampus. This change was characterized by central chromatolysis and resembled the “primäre Reizung” of Nissl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00696570
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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