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  • 1
    Electronic Resource
    Electronic Resource
    Hepatic mitochondrial redox state in hypotensive brain-dead patients and an effect of dopamine administration (1991)
    Springer
    Intensive care medicine 17 (1991), S. 103-107 
    Details
    ISSN: 1432-1238
    Keywords: Brain-dead patients ; Arterial blood ketone body ratio ; Dopamine ; Hepatic mitochondrial redox state ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Arterial blood ketone body ratio, reflecting hepatic mitochondrial redox state, was measured in 26 brain-dead patients who were hypotensive but hemodynamically stable. All of them had substantially normal hepatic function. In 18 of the patients, blood ketone body ratio was maintained within the normal range in spite of hypotension. This was in marked contrast to the markedly decreased blood ketone body ratio often observed in patients in shock. This phenomenon was especially conspicuous in those who had not received exogenous dopamine infusion. It is suggested that hepatic mitochondrial redox state can probably be maintained despite systemic hypotension in brain-dead patients. Dopamine administration, on the other hand, is suggested to be a contributing factor to the reduction of hepatic mitochondrial redox state in hypotensive brain-dead patients. This study may provide a guideline for effective preservation of hepatic function in the body of brain-dead patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691432
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Difference in in vivo receptor binding between [3 H]N-methylspiperone and [3 H]raclopride in reserpine-treated mouse brain (1991)
    Springer
    Journal of neural transmission 85 (1991), S. 1-10 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine ; D2 receptors ; reserpine ; N-methylspiperone ; raclopride ; in vivo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vivo binding of [3 H]N-methylspiperone (NMSP) and [3 H]raclopride was compared in mice treated with reserpine (5 mg/kg, 24 hr prior to the tracer injection). With both radioligands, selective accumulation of radioactivity in the striatum following intravenous injection was observed, whereas a relatively low accumulation and a rapid decline in radioactivity in the cerebellum was seen. Reserpine significantly decreased [3 H]NMSP binding in vivo, however it increased [3 H]raclopride binding. By compartment model analysis, it was found that the decrease in [3 H]NMSP binding was primarily due to the decrease in the association rate (K3) and the increase in [3 H]raclopride was due to the decrease in the dissociation rate (K4) in vivo. As both Kd and Bmax of dopamine D2 receptors have been reported to be unaltered by reserpine, these results suggested that some unknown factors except Kd and Bmax which influence on in vivo binding of receptors might be changed by reserpine. These results revealed that it is of importance to measure kinetics of ligand-receptor binding in vivo rather than static analysis. These two different types of radioligands can be combined to reveal functional roles of dopamine receptor in vivo, especially in the study of the human brain with positron emission tomography (PET).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244652
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene (1994)
    Springer
    Journal of neural transmission 97 (1994), S. 41-49 
    Details
    ISSN: 1435-1463
    Keywords: Dopamine ; dopaminergic neuron ; locomotor activity ; methamphetamine ; nicotine ; transgenic mice ; tyrosine hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277961
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    Paper (German National Licenses)
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