ISSN:
1432-2072
Keywords:
Opioid peptides
;
d-Met2,Pro5-enkephalina-mide
;
Prolactin
;
Growth hormone
;
TSH
;
Methysergide
;
Bromocriptine
;
Dopaminergic agonists
;
Serotonergic antagonists
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract d-Met2,Pro5-enkephalinamide (EA) 10 mg, given SC, induced a dramatic rise in serum prolactin (PRL) and growth hormone (GH) levels in healthy male volunteers. The TSH content was also moderately elevated. Naloxone 0.8 mg administered IV abolished these effects. Bromocriptine 2.5 mg given per os also antagonized EA-induced PRL and TSH release but potentiated the GH surge. Methysergide 2.0 mg administered orally partially reversed EA-elicited PRL release, further augmented GH liberation and did not modify TSH output. The data indicate that inhibition of the dopaminergic tone and/or activation of certain serotonergic mechanisms play an important role in the EA-induced release of PRL and TSH. However, primarily other neurotransmitters might mediate the GH liberation elicited by this opioid peptide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00180834
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